Transcriptional control of brown fat determination by PRDM16.

By P. Seale, S. Kajimura, Wenli Yang, Sherry Chin, Lindsay M. Rohas, Marc Uldry, G. Tavernier, D. Langin, B. Spiegelman. Cell Metabolism, 2007

1,203 citations recorded by the source corpus.

Subfields: Biochemistry, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/fe262b6696c5465dafed8fd99707cce9066e5e9d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. B. Spiegelman
2. P. Seale
3. H. Ohno
4. Gerald I. Shulman
5. C. R. Kahn
6. Jun Wu
7. E. Rosen
8. Kosaku Shinoda

In Epidemiology

1. B. Spiegelman
2. S. Kajimura
3. E. Rosen
4. P. Seale
5. Y. Tseng
6. C. R. Kahn
7. S. Gesta
8. H. Ohno

In Physiology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. E. Rosen
5. Jun Wu
6. Y. Tseng
7. C. R. Kahn
8. S. Gesta

Citations in the corpus

• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells (2012, background): “Indeed, it has been shown that PRDM16 expression in primary and immortalized white adipocytes is sufficient to activate a large array of brown-fat selective genes via interacting with several transcriptional factors such as PPARc and PGC1a [26,32,44].”
• PPAR agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein (2012, positive): “It does this through interactions with several transcription factors such as C/EBPβ, PPARγ, PGC-1α β and C-terminal binding proteins (Kajimura et al., 2009; Kajimura et al., 2008; Seale et al., 2008; Seale et al., 2007).”
• Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch (2014, background): “Pgc1a expression is reduced in our KOs, consistent with PRDM16 being upstream of PGC1a (Seale et al., 2007).”
• Developmental origin of fat: tracking obesity to its source. (2007, positive): “Forced expression of prdm16 in a white preadipocyte cell line or WAT in vivo activates a robust brown fat phenotype (Seale et al., 2007).”
• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “PRDM16 was shown to be sufficient and necessary for the brown fat phenotype in cell culture models and sufficient to promote browning in visceral fat under b-adrenergic stimulation (Seale et al. 2007).”
• Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. (2011, background): “We previously showed that transgenic expression of Prdm16 in all adipose depots (using the –5 kb aP2 promoter/enhancer; also referred to as Fabp4) caused no morphological or molecular changes in the iBAT or WAT of mice under basal conditions (53).”
• Beige Adipocytes are a Distinct Type of Thermogenic Fat Cell in Mouse and Human (2012, methodology): “Cell Transplantations Immortalized clonal inguinal cells (3 3 107) were implanted subcutaneously into 7- to 9-week-old male NCr nude mice (Taconic; n = 5–8 mice per group) according to the methods described previously (Seale et al., 2007).”
• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “Intriguingly, PRDM16 expression in white adipocytes not only activates the brown fat-selective gene program but also represses the white fat- or muscle-selective gene program (Kajimura et al., 2008; Seale et al., 2007, 2008).”
• What We Talk About When We Talk About Fat (2014, positive): “This suggests that other factors might also be important in brown fat identity, which led to the identification of PRDM16, another coregulator (Seale et al., 2007).”