Selective Blockade of MicroRNA Processing by Lin28

By Srinivas R. Viswanathan, George Q. Daley, R. I. Gregory. Science, 2008

1,539 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/50794319d60230e771a9e5ad967367c838d9acab

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. David P. Bartel
2. John S. Mattick
3. Scott M. Hammond
4. Phillip A. Sharp
5. V. Narry Kim
6. Thomas Tuschl
7. Frank J. Slack
8. Marcel E. Dinger

In Molecular Biology

1. David P. Bartel
2. John S. Mattick
3. Richard A. Young
4. Phillip A. Sharp
5. Scott M. Hammond
6. Thomas Tuschl
7. V. Narry Kim
8. Phillip D. Zamore

Citations in the corpus

• MicroRNAs in development and disease. (2011, background): “In agreement, it was found that lin-28 binds the loop structure of let-7 and inhibits its processing by both Drosha in the nucleus (448, 638) and Dicer in the cytoplasm (518).”
• Non‐coding RNAs: regulators of disease (2010, background): “Likewise, the pluripotency factor LIN28 can bind to the conserved loop of the primary let-7 transcript (pri-let-7) to directly inhibit the Drosha cleavage steps [75–77] and can inhibit Dicer cleavage directly or by facilitating premiRNA degradation [78,79].”
• Small RNAs and Their Roles in Plant Development (2009, background): “The accumulation of mouse let-7 miRNA is regulated by LIN-28 at a post-transcriptional step, either pri-let-7 processing or stability of pre-let-7, or both (Heo et al. 2008, Viswanathan et al. 2008).”
• miRNAs in human cancer (2010, background): “First, LIN28A blocks processing of tumour suppressor pri- and pre-let-7 [81–85], thus maintaining expression of genes that drive self-renewal and proliferation (reviewed in [86]); tumours that express LIN28A were indeed shown to be poorly differentiated and more aggressive than LIN28A-negative tumou”
• Origins and Mechanisms of miRNAs and siRNAs (2009, background): “Drosha-mediated cleavage is inhibited by Lin28 (Heo et al., 2008; Newman et al., 2008; Viswanathan et al., 2008), as is Dicer-medi-ated cleavage (Heo et al., 2008; Rybak et al., 2008).”
• Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “…to block accumulation of mature let-7 by repression of both Drosha and Dicer activities (Heo et al., 2008; Newman et al., 2008; Rybak et al., 2008; Viswanathan et al., 2008), recent studies demonstrate that LIN-28 can induce 30 terminal uridylation of pre-let-7 miRNA in mouse embryonic stem (ES)…”
• Child health, developmental plasticity, and epigenetic programming. (2011, background): “(227) reported that the LIN28B protein product selectively blocks the processing of pri-let-7 miRNAs in embryonic cells by blocking microprocessor-mediated cleavage of pri-let-7 miRNAs.”
• Control of Embryonic Stem Cell State (2011, background): “Loss of the key ESC transcription factors leads to downregulation of the miRNA regulator Lin28, withconsequentmaturationof theLet-7miRNAs,whicharehighly expressed in somatic tissues where they inhibit self-renewal genes (Melton et al., 2010; Viswanathan et al., 2008).”
• MicroRNA control of signal transduction (2010, background): “The levels of mature let-7 increase during differentiation, but this is not caused by an increase in its transcription rat”
• The role of let-7 in cell differentiation and cancer. (2010, background): “Two groups set out to biochemically identify this factor from differentiating P19 embryonic stem cells by coupling pre-let-7 molecules to beads and pulling down proteins that bound to the loop region of let-7 (Newman et al. 2008, Viswanathan et al. 2008).”
• The Lin28/let-7 axis regulates glucose metabolism (2011, background): “Another mechanism for let-7 downregulation involves the RNA-binding proteins Lin28a and Lin28b (collectively referred to as Lin28a/b), which are highly expressed during normal embryogenesis and upregulated in some cancers to potently and selectively block the maturation of let-7 (Heo et al., 2008; N”
• Induced pluripotency: history, mechanisms, and applications. (2010, background): “Indeed, lin28 represses let-7 miRNAs (Viswanathan et al. 2008), which are negative regulators of c-Myc translation (Akao et al. 2006; HH Kim et al. 2009), thus establishing a link between the two reprogramming cocktails (Oct4, Klf4, Sox2, and c-Myc, and Oct4, Sox2, Nanog, and Lin28).”