Non‐coding RNAs: regulators of disease

By Ryan J. Taft, Ken C. Pang, Tim R. Mercer, Marcel E. Dinger, John S. Mattick. Journal of Pathology, 2010

1,036 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/58b9525c085934c0b797df585ca8426fb4b2c92b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

The functional role of long non-coding RNA in human carcinomas (2011, background): “One such player, the newly discovered long non-coding RNA (lncRNA) genes, demonstrate developmental and tissue specific expression patterns, and aberrant regulation in a variety of diseases, including cancer [18-27].”
Large-scale prediction of long non-coding RNA functions in a coding–non-coding gene co-expression network (2011, background): “The fact that ncRNAs have regulatory roles in a wide range of processes have led to the realization that question of ncRNA functions cannot be ignored (4), and excavating the hidden layer of lncRNA function is necessary in order to obtain a comprehensive understanding of the operational mechanisms o”
Gene regulation by the act of long non-coding RNA transcription (2013, background): “Although the function of most lncRNAs is unknown, the number of characterized lncRNAs is growing and many publications suggest they play roles in negatively or positively regulating gene expression in development, differentiation and human disease [2,5-10].”
Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “Recent large-scale genome sequencing projects have revealed that only a very small percentage of the mammalian genome encode mRNAs that translate into proteins.”
NONCODE v3.0: integrative annotation of long noncoding RNAs (2011, background): “lncRNAs have already been shown to play key roles in imprinting control, circuitries controlling pluripotency and differentiation, immune responses, chromosome dynamics and human diseases (2,10).”
Long non-coding RNAs and complex diseases: from experimental results to computational models (2016, background): “…to find that the mutations and dysregulations of lncRNAs are closely related to the development and progression of many kinds of human diseases [2, 16, 69, 82, 97–99], such as breast cancer [21, 100], prostate cancer [22, 23], hepatocellular cancer (HCC) [101], colon cancer [24], bladder…”
The emergence of lncRNAs in cancer biology (2011, background): “lncRNAs also commonly exhibit splicing of multiple exons into a mature transcript, as do many antisense RNAs, but not RNAs Small ncRNAs The diversity of small ncRNAs has perhaps grown the most; several dozen classes of small ncRNAs have been proposed (10, 11).”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “This is perhaps not surprising because the genome is highly transcribed from intergenic regions and many disease variants map far from genes; thus, the likelihood of interrupted lncRNAs is high (101).”
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs (2012, background): “Finally, we refer the reader to an excellent review article that covers the role of lncRNAs in human disease in depth (76).”
On the classification of long non-coding RNAs (2013, background): “Small ncRNAs include many different RNAs, such as microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), piwiRNAs (piRNAs).(8) Undoubtedly, the definition of lncRNA merely based on length is arbitrary.”