Child health, developmental plasticity, and epigenetic programming.
By Hochberg Z, F. R, C. M, Fraga M, J. C., Carel Jc, Boileau P, L. Y, Deal Cl, L. K. and 8 more. Endocrine reviews, 2011
627 citations recorded by the source corpus.
Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.
Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/31ff18445ed4836640b4db07fdb6be181ba4005e
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In Molecular Biology
In Pediatrics, Perinatology and Child Health
Citations in the corpus
- Transgenerational Epigenetic Inheritance: myths and mechanisms (2014, neutral): “Such phenomena have now been put under the umbrella of DOHaD ‘‘developmental origins of health and disease,’’ which proposes that a wide range of environmental conditions during embryonic development and early life determine susceptibility to disease during adult life (Hochberg et al., 2011).”
- Drivers of human development: How relationships and context shape learning and development1 (2020, background): “The prenatal period and the first two years of life provide a useful example (e.g., Hochberg et al., 2011).”
- Resilience in developing systems: the promise of integrated approaches (2016, background): “Developmental plasticity affords the opportunity for an organism to adapt to a wider range of environments by adjusting the developing phenotype to the environment in which it will live (Del Giudice, ellis, & Shirtcliff, 2011; Hochberg et al., 2011).”