Stepwise reprogramming of B cells into macrophages.

By Huafeng Xie, M. Ye, R. Feng, Thomas Graf. Cell, 2004

1,014 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4f42e42f2d34392f43e7977b32bf9448272c7c89

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In Immunology

Citations in the corpus

Pax5: the guardian of B cell identity and function (2007, background): “Forced retroviral expression of C/EBP-α in unfractionated B lymphocytes from the bone marrow or spleen leads to efficient transdifferentiation of the infected B cells into functional macrophages within 5 days of in vitro cultur”
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. (2008, positive): “In addition, C/EBPa induced upregulation of components of a myeloid transcriptional network (Laiosa et al., 2006; Xie et al., 2004).”
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. (2006, background): “There is considerable controversy concerning the plasticity of stem and progenitors, and there are numerous examples where lymphoid lineage cells were experimentally converted to macrophages (Kondo et al., 2000, Iwasaki-Arai et al., 2003, and Xie et al., 2004).”
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. (2007, background): “Several reports have demonstrated that lineage conversion can occur in already lineage committed cells, most convincingly evidenced by the presence of immunoglobulin or T cell receptor rearrangements in myeloid progeny (Drynan et al., 2005; Kondo et al., 2000; Xie et al., 2004).”
Transcriptional Regulation and its Misregulation in Disease (2013, positive): “…expressed in various cell types (Buganim et al., 2012; Davis et al., 1987; Huang et al., 2011; Ieda et al., 2010; Kajimura et al., 2009; Marro et al., 2011; Pang et al., 2011; Sekiya and Suzuki, 2011; Takahashi and Yamanaka, 2006; Vierbuchen et al., 2010; Xie et al., 2004; Zhou et al., 2008).”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “…molecular definition of different pluripotent states and strategies to convert one cell state into another; (2) molecular concepts of somatic cell reprog- 508 Cell 143, November 12, 2010 ª2010 Elsevier Inc. ramming to pluripotency; and (3) direct transdifferentiation between somatic cell states.”
Systems biology of stem cell fate and cellular reprogramming (2009, background): “(thus potentially providing a patient-specific source of pluripotent stem cells), as well as be reprogrammed to other adult cell types without intermediate reversion to a pluripotent stat”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “…megakaryocyte programs (Visvader et al. 1992; Kulessa et al. 1995); C/EBPa and C/EBPb, whose expression in B cells activates the macrophage program (Xie et al. 2004); and, in perhaps the most dramatic example, Pax6, whose expression can cause the appearance of additional eyes growing out of a fly…”
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. (2007, background): “Indeed, lineage specification in lymphoid systems might be as dependent on the absence of an inhibitory factor(s) as on the presence of an inducer (Souabni et al., 2002; Xie et al., 2004; Rothenberg and Dionne, 2002).”
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, positive): “The experimental transdifferentiation of B cells into macrophages using the transcription factors CCAAT-enhancer-binding protein-α (CEBPα) and CEBPβ provides a good example of this second mechanis”
Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “In addition, in 2004, the mouse C/EBP family of transcription factors was shown by Graf and colleagues to have a key role in the conversion of one blood cell type to another (from lymphocytes to macrophages”