Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.

By J. Hanna, S. Markoulaki, Patrick Schorderet, Bryce W. Carey, C. Beard, Marius Wernig, M. Creyghton, Eveline J. Steine, John P. Cassady, Ruth K. Foreman and 3 more. Cell, 2008

877 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0e7ac5834714ada07983671c737f8fd67edd6c94

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. (2008, background): “Previous studies demonstrated that stable genomic integration and high expression of four factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28, can reprogram fibroblast cells, B cells, and liver and stomach epithelial cells into induced pluripotent stem cells (iPSCs) (Hanna et al., 2008; Takahashi”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “However, iPSCs from mouse (Hanna et al., 2008) and human (Loh et al., 2010; Seki et al., 2010; Staerk et al., 2010) were recently generated from lymphocytes with high efficiency, providing conclusive evidence that terminally differentiated cells can be reprogrammed to pluripotency.”
Epigenetic memory in induced pluripotent stem cells (2010, background): “These studies involve “secondary” iPSC lines derived from neural progenitor cells (NP-iPSC 29 ) and B-lymphocytes (Bl-iPSC 30 ) of mice chimerized with iPSC carrying proviruses that express doxycycline-inducible reprogramming factors from identical proviral integration sites.”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “terminally differentiated somatic cells such as B and T lymphocytes (Hanna et al., 2008).”
Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition (2008, methodology): “Fully reprogrammed iPS cells have previously been generated from fibroblasts [1,29] and other cell types [3,5,28] without a defined pre-iPS intermediate.”
Pluripotency: Toward a gold standard for human ES and iPS cells (2009, background): “X - No live born mice have been produced from reprogrammed mouse cells, but some iPS derived embryos have been reported (Hanna et al., 2008).”
A fresh look at iPS cells. (2009, background): “…mouse iPS cells have been generated from bone marrow cells (Takahashi and Yamanaka, 2006), hepatocytes and gastric epithelial cells (Aoi et al., 2008), pancreatic cells (Stadtfeld et al., 2008a), neural stem cells (Kim et al., 2008; Silva et al., 2008), and B lymphocytes (Hanna et al., 2008).”
Epigenetic reprogramming and induced pluripotency (2009, background): “Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “2009), and that inhibition of lineage-specific factors (Hanna et al. 2008; Mikkelsen et al. 2008) can facilitate the reprogramming process.”