Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

By C. Pronk, Derrick J. Rossi, R. Månsson, J. Attema, G. Norddahl, Charles K. F. Chan, Mikael Sigvardsson, Irving L. Weissman, David Bryder. Cell Stem Cell, 2007

692 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/ecb942124f6643a0f78c74b6715c8db75509bd92

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Aviv Regev
2. Benjamin L. Ebert
3. A. Wagers
4. E. Laurenti

In Hematology

1. J. Dick
2. Benjamin L. Ebert
3. A. Wagers
4. E. Laurenti
5. E. Passegué

In Immunology

1. Aviv Regev
2. J. Dick
3. K. Murphy
4. A. Wagers

Citations in the corpus

• Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (2015, methodology): “Enrichment analysis using gene sets from lineage-restricted progenitors (Pronk et al. 2007; Sanjuan-Pla et al. 2013) revealed a lymphoid bias for gene-set1 and pre-megakaryocyte/erythroid and megakaryocyte progenitor bias for gene-set2 (Figure 5F).”
• The lung is a site of platelet biogenesis and a reservoir for hematopoietic progenitors (2017, neutral): “3g) 22 .”
• Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages (2012, background): “8, A and B; Pronk et al., 2007).”
• Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions (2015, positive): “In addition, based on surface marker expression, MPP2 could be positioned upstream of Pre-MegE and MPP3 upstream of Pre-GM (Figure S1E) (Pronk et al., 2007), thereby establishing a connection between these MPP subsets and myeloid progenitors committed to their dominant lineage fate, similar to the l”
• The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance (2011, neutral): “In contrast, the HSPCs of FL origin still able to reconstitute lethally irradiated mice can also form myeloproliferative foci in the BM.”
• DISTINCT ROUTES OF LINEAGE DEVELOPMENT RESHAPE THE HUMAN BLOOD HIERARCHY ACROSS ONTOGENY (2015, background): “In the murine bone marrow niche, up to a quarter of LT-HSCs lie directly adjacent to Mks (36–38).”