Hedgehog Signaling in Development and Cancer

By Jin Jiang, C. Hui. Developmental Cell, 2008

1,005 citations recorded by the source corpus.

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/74d766b99eca342bc888d8c01168f8ecb1a2dfff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Shinsuke Niwa
2. Yosuke Tanaka
3. C. Hui
4. N. Hirokawa
5. Xiaochun Li
6. Xiaofeng Qi
7. J. Raff
8. Erich A. Nigg

In Pathology and Forensic Medicine

1. N. Hirokawa
2. Shinsuke Niwa
3. Yosuke Tanaka
4. Xiaochun Li
5. Xiaofeng Qi
6. B. Yoder

Citations in the corpus

• Centrioles, centrosomes, and cilia in health and disease. (2009, background): “It is also important in adult tissues, as it can promote the proliferation of adult stem cells (Ahn and Joyner, 2005) and is one of the most frequently upregulated signaling pathways in human cancers (Jiang and Hui, 2008).”
• Mechanistic insights into the generation and transduction of Hedgehog Signaling (2020, background): “This activates the Glioma-associated oncogene (GLI) transcription factors to up-regulate target genes [4, 33].”
• G protein-coupled receptors: novel targets for drug discovery in cancer (2010, background): “In adult tissues, the HH pathway contributes to stem cell maintenance, tissue repair and regeneration, but it is also implicated in the development of basal cell carcinoma, a subset of medulloblastoma and other sporadic malignancies, including those in the pancreas, prostate, lung and breast, as con”
• The Primary Cilium as a Complex Signaling Center (2009, background): “Hedgehog (Hh) is a secreted protein regulating a vast number of developmental processes in both vertebrates and invertebrates [57,58].”
• Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. (2010, positive): “Neurons and neural progenitor cells contain primary cilia, which are essential for hedgehog signaling during development and carcinogenesis (Jiang and Hui, 2008).”
• Gli proteins in development and disease. (2011, background): “Molecular genetic analysis in mice and other model systems has established the central role of Gli proteins in many Hh-dependent developmental processes ( Jiang & Hui 2008, Varjosalo & Taipale 2008).”