Cancer metastasis: building a framework.

By G. Gupta, J. Massagué. Cell, 2006

4,212 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b70b188447f10cf151ccfb799a0e83c0d3d12660

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In Oncology

Citations in the corpus

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. (2008, background): “Disseminating tumor cells that enter into the bloodstream lose their attachment to the extracellular matrix, resulting in induction of the form of apoptosis termed anoikis ( 1 ).”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “The loss of E-cadherin is a rate-limiting step in the progression of invasive carcinoma and a fundamental event in the epithelial to mesenchymal transition, which is associated with metastasis (Perl et al. 1998; Gupta and Massagué 2006).”
Metastasis: from dissemination to organ-specific colonization (2009, background): “jpg" NDATA ITEM> ]> Tumour progression towards metastasis is often depicted as a multistage process in which malignant cells spread from the tumour of origin to colonize distant organ”
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “Introduction Cancer is one of the major health problems in the Western world, with metastasis being the most critical concern, because it accounts for over 90% of cancer mortality (1).”
Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer (2017, background): “Epithelial-to-mesenchymal transition (EMT) has been suggested as a driver of epithelial tumor spread (Gupta and Massagué, 2006; Lambert et al., 2017).”
Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, neutral): “vitro [54,55].”
Tumor entrained neutrophils inhibit seeding in the premetastatic lung (2011, positive): “It has become clear that key events in the metastatic cascade, such as migration, intravasation, extravasation, and re-initiation at the future site of metastasis, are determined at least in part in a cell autonomous manner (Gupta and Massagué, 2006).”
EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “The dissemination of cancer cells from primary tumors and their subsequent seeding of new tumor colonies in distant tissues involves a multi-step process known as the invasionmetastasis cascade (Fidler, 2003; Gupta and Massague, 2006; Talmadge and Fidler, 2010).”
A microRNA DNA methylation signature for human cancer metastasis (2008, background): “Metastasis is responsible for 90% of deaths in patients with solid tumors (10, 11), so understanding its pathogenesis at the systemic, cellular, and molecular levels has become one of the most ambitious goals in cancer research (10, 11).”
TGFβ in Cancer (2008, background): “new host microenvironment, and eventually grow into lethal tumor colonies in those distal organs (Fidler, 2003; Gupta and Massagué, 2006).”
Genetic determinants of cancer metastasis (2007, background): “Recent reviews have comprehensively analysed the biological traits and steps of cancer metastasi”
Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “…spread of carcinoma cells is routinely observed in human tumors and represents an important prognostic marker for disease progression, dissemination via the hematogenous circulation appears to represent the major mechanism by which metastatic carcinoma cells disperse (Gupta and Massagué, 2006).”