Module map of stem cell genes guides creation of epithelial cancer stem cells.

By D. Wong, Helen Liu, T. Ridky, D. Cassarino, Eran Segal, Howard Y. Chang. Cell Stem Cell, 2008

731 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/9272dc4c446b4112ecf5c908f2f8ba5716b5c9c4

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Citations in the corpus

Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation (2010, positive): “Hyperactivated Stem Cell-Associated Programs: A Potential Mechanism Underlying Tumors that Arise Following Snf5 Inactivation or Overexpression of PcG Proteins Stem cell-associated signatures have recently been found to be enriched in tumors with more aggressive behavior and poorer prognosis (Ben-Por”
Cancer stem cells: current status and evolving complexities. (2012, background): “…cell signature was found to increase with tumor grade and mortality in multiple tumor types (Shats et al., 2011), while an ESC-like transcriptional program evident in 722 Cell Stem Cell 10, June 14, 2012 ª2012 Elsevier Inc. diverse epithelial cancers predicted poor prognosis (Wong et al., 2008).”
Intratumoral Tcf1+PD‐1+CD8+ T Cells with Stem‐like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy (2019, positive): “In agreement with these stem cell-like properties, transcripts overrepresented in Tcf7 P14 TILs significantly overlapped with a subset of genes expressed by adult stem cells (Wong et al., 2008) or by hematopoietic stem/progenitor cells but not by mature hematopoietic cells (Figure S7A; Ivanova et al”
Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome (2011, methodology): “[15]), of the correlations of the same module with its cell cycle genes removed (red) and of all of the genes spotted on the microarray (black).”
m6A RNA modification controls cell fate transition in mammalian embryonic stem cells (2014, methodology): “Multi-dimensional gene set enrichment analysis over DAVID Gene Ontology terms and stem cell gene sets (Wong et al., 2008) were performed using Genomica (Segal et al.”
Metastasis: from dissemination to organ-specific colonization (2009, background): “Indeed, different subsets of solid tumours that express transcriptional modules that are unique to embryonic stem cells have a higher probability of general recurrenc”
Myc's broad reach. (2008, background): “As mentioned before, both the liver tumors and the lymphomas are transplantable, documenting that they contain tumor-initiating cells; indeed, limiting dilution analysis shows that the introduction of Myc into primary keratinocytes that have been transformed by an oncogenic allele of Ras and IKB str”
The tumorigenicity of human embryonic and induced pluripotent stem cells (2011, background): “10 ), and remarkable similarities in their overall gene expression pattern”
Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “However, neither study provided evidence for a functional link between the gene expression signature and adult stem cell biology, either normal or malignant (Ben-Porath et al., 2008; Wong et al., 2008).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “The authors argue that the ES cell-like module identified before (Ben-Porath et al, 2008) (Wong et al., 2008) is composed mainly of”
MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells (2009, neutral): “The miR-34-mediated reduction of the CD44+/CD133+ CSC is associated with the potent and simultaneous inhibition of its downstream target genes Notch and Bcl-2, genes involved in stem cells self-renewal and survival, socalled ‘‘stem cell genes’’ or ‘‘stemness genes’’ [6,41,42,43].”
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, background): “This knowledge also has begun to shed light on human disease, as elementsof the EScell gene expression programare recapitulated in cancer cells (Wong et al., 2008; Ben-Porath et al., 2008).”
P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation (2008, neutral): “…versus the 59 remaining tumors (1.40x, p=2.20x10 −3 ) or versus the 12 p53 only mutant tumors (1.46x, p=1.54x10 −3 ). c-MYC is well-known for its roles in cell cycle progression and apoptosis 18 as well as stem cell self-renewal and differentiation during development and oncogenic processes 19–22 .”