Hepatocellular carcinoma pathogenesis: from genes to environment

By P. Farazi, R. DePinho. Nature Reviews. Cancer, 2006

2,004 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/c9d8c4f12f55255770e1ba420dd6ab9b2b68f456

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. J. Llovet
2. Jordi Bruix1 , 2
3. M. Sherman
4. E. Brunt
5. Robert F. Schwabe
6. V. Mazzaferro
7. S. Friedman
8. Yujin Hoshida

In Hepatology

1. J. Llovet
2. Jordi Bruix1 , 2
3. M. Sherman
4. V. Mazzaferro
5. Peter R. Galle
6. E. Brunt
7. Yujin Hoshida
8. Robert F. Schwabe

Citations in the corpus

• Focal Gains of Vascular Endothelial Growth Factor A and Molecular Classification of Hepatocellular Carcinoma (2008, background): “Hepatitis C virus is the most prevalent etiology in the United States and Europe, whereas hepatitis B virus is endemic in Asia and Africa (1, 2).”
• Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. (2012, background): “, mitogen-activated protein kinases, the Janus kinase/signal transducers and activators of transcription [STAT] kinase system, and the phosphoinositide-3-kinase/Akt pathway) [53,54].”
• The H19 Non-Coding RNA Is Essential for Human Tumor Growth (2007, background): “Although considerable effort has focused on unraveling the molecular pathogenesis of HCC during the last few years, constructive knowledge remains mostly unknown [1].”
• Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma (2018, neutral): “Molecular-targeting drugs for HCC treatment are promising, however their effectiveness might be restricted because of the complex multi-step processes and heterogeneity of HCC [8].”
• Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis (2017, background): “HCC carcinogenesis induced by alcohol is associated with recurrent inflammation and cycles of hepatocyte necrosis and regeneration with oxidative stress, finally resulting in cirrhosis.[42]”
• Novel advancements in the management of hepatocellular carcinoma in 2008. (2008, background): “The increasing knowledge in the molecular pathogenesis of HCC as well as the introduction of molecular targeted therapies in oncology have created an encouraging trend in the management of this malignancy (see reviews on [39,112]).”
• The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer (2016, background): “Key mechanisms include ROS-mediated DNA damage and genomic instability in hepatocytes (21), as well as inhibitory effects on T lymphocyte–mediated tumor immunosurveillance (22).”
• Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma (2009, background): “This complexity makes it difficult to identify the causal genetic events promoting HCC development and progression (2, 3).”
• Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial , (2012, background): “Similarly, chronic alcohol use induces oxidative damage and inflammation in the liver, with subsequent repair mechanisms causing cirrhosis and genetic aberrations [22].”