An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

By I. Ben-Porath, Matthew Thomson, V. Carey, Ruping Ge, George W. Bell, Aviv Regev, R. Weinberg. Nature Genetics, 2008

2,550 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/0f3be012b9d537a067c1c161d87237a0dd5c9d53

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Citations in the corpus

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, background): “This knowledge also has begun to shed light on human disease, as elementsof the EScell gene expression programare recapitulated in cancer cells (Wong et al., 2008; Ben-Porath et al., 2008).”
Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. (2010, background): “Recently, Ben-Porath et al. described an embryonic stem-like signature, which could predict, in breast cancers, tumor grade and several additional features, including clinical outcome (Ben-Porath et al., 2008).”
Mechanisms of Polycomb gene silencing: knowns and unknowns (2009, background): “Moreover, PRC2 target genes are key components of expression signatures that are associated with aggressive forms of prostate and breast cancer”
An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression (2010, methodology): “We first derived previously reported Polycomb gene signatures associated with ESCs and poorly differentiated tumors, including target genes of Polycomb repressive complex 2 (PRC2), of PcG proteins SUZ12 and EED, and of H3K27me3 (Ben-Porath et al., 2008).”
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction (2008, background): “Another oncogene associated with a poor prognosis in glial tumors is Myc (14).”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, positive): “In support of this model, cancer cells frequently exhibit stem cell-like gene expression and chromatin structure signatures (Ben-Porath et al., 2008; Widschwendter et al., 2007).”
The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer? (2010, background): “We have recently shown that zEB1 increases stem-cell properties and the tumorigenic capacity in pancreatic cancer cells (Wellner et al, 2009), and ES cells have been shown to express zEB1 (Ben-porath et al, 2008), which is reduced on their differentiation.”
Triple-negative breast cancer--current status and future directions. (2009, background): “BLBCs commonly express an ‘embryonic stem-cell signature’ [13].”
The tumorigenicity of human embryonic and induced pluripotent stem cells (2011, background): “10 ), and remarkable similarities in their overall gene expression pattern”
Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation (2010, positive): “Hyperactivated Stem Cell-Associated Programs: A Potential Mechanism Underlying Tumors that Arise Following Snf5 Inactivation or Overexpression of PcG Proteins Stem cell-associated signatures have recently been found to be enriched in tumors with more aggressive behavior and poorer prognosis (Ben-Por”
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer (2010, background): “Finally, poorly differentiated and aggressive cancers show a gene expression signature related to that of embryonic stem cells (Ben-Porath et al., 2008).”