Tlr4: central component of the sole mammalian LPS sensor.

By B. Beutler. Current Opinion in Immunology, 2000

838 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/4a42c2558fbcd88a330e9ed2b6dea0385b8cb999

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In Cancer Research

1. Shizuo Akira
2. S. Ghosh
3. T. Kaisho
4. M. Abreu
5. J. Avruch
6. Guolong Zhang
7. J. Tsai
8. E. Cario

In Immunology

1. Shizuo Akira
2. M. Abreu
3. S. Ghosh
4. T. Kaisho
5. S. Rivest
6. M. Febbraio
7. J. Avruch
8. J. Kyriakis

In Microbiology

1. Shizuo Akira
2. J. Avruch
3. S. Ghosh
4. Guolong Zhang
5. E. Cario
6. B. K. Pedersen
7. M. Abreu
8. D. Podolsky

Citations in the corpus

• Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. (2001, background): “The ability of these mice to respond to LPS had been genetically linked to the Lps locus on chromosome 4 (17).”
• Receptor-Mediated Monitoring of Tissue Well-Being Via Detection of Soluble Heparan Sulfate by Toll-Like Receptor 41 (2002, background): “mice, do not respond to the presence of LPS (31).”
• Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. (2001, background): “modes of receptor activation, the intracellular extensions of TNFR family receptors are quite divergent (7, 17, 18, 284, 316, 323).”
• Toll-like receptor function and signaling. (2006, background): “The cell walls of gram-negative bacteria contain LPS, an immune adjuvant identified first as a TLR ligand.(6) LPS is recognized by TLR4 and a TLR4-associated soluble factor, MD-2, derived from the host.”
• Human Toll-like receptor 4 recognizes host-specific LPS modifications (2002, background): “Much evidence indicates that TLR4 transduces the signals that lead to the production of inflammatory mediators in response to LP”
• Muscle as an endocrine organ: focus on muscle-derived interleukin-6. (2008, background): “NF B is then able to translocate into the nucleus and to exert its transcriptional effects on the immunologically relevant genes such as IL-6, TNF- , and IL-1 that mediate the classic inflammatory response (5, 8, 27, 127, 178, 192, 196).”
• Vitamin D Inhibits Monocyte/macrophage Pro-inflammatory Cytokine Production by Targeting Mitogen-Activated Protein Kinase Phosphatase 1 (2012, background): “The MAPKs activated by LPS [ERK, JNK, and p38 (12)] are critical”
• Innate immunity: the missing link in neuroprotection and neurodegeneration? (2002, background): “The observations that mutations of the mouse Lps locus abolish the response to LPS, and that this locus encodes TLR4, provided the first evidence that this particular receptor might be involved in the innate immune response to Gram-negative bacteri”
• Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease (2000, background): “Spontaneous mutations of TLR4 could prime individuals experiencing acute infections to develop especially severe disease (3).”
• Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells1 (2001, background): “Moreover, the exceptionally high variability in TLR surface expression that we observed among normal donors might indicate a high variability in the way different individuals respond to PAMPs.”