Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells1

By A. Visintin, A. Mazzoni, J. H. Spitzer, D. Wyllie, S. Dower, D. Segal. Journal of Immunology, 2001

677 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/2b64643277667417cab6d88b78cc10851bb97995

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In Immunology

1. Yong‐jun Liu
2. S. Lehnardt
3. V. Hornung
4. J. Kuiper
5. G. Hartmann
6. Yuanqing Liu
7. S. Miller
8. J. Olson

Citations in the corpus

• Microglia Initiate Central Nervous System Innate and Adaptive Immune Responses through Multiple TLRs1 (2004, background): “Immature dendritic cells express TLR1, 2, 4, and 5; however, expression of these TLRs decreases upon maturation and TLR3 expression is induced (27).”
• Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens (2001, background): “The progressive downregulation of TLRs during pre-DC differentiation into imDCs and mature DCs, as shown here and in previous studies (18, 42), indicates a functional switch of DC lineage from microbial antigen recognition to antigen presentation, thus priming naive T cells and instructing them to d”
• Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury (2009, background): “Functional TLR4-mediated signaling was reported in peripheral APCs despite low detectable surface expression, suggesting that low levels of expression are sufficient to induce signaling (Visintin et al., 2001).”
• A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species (2014, background): “This TLR4 expression level decreases markedly during immature DC formation but remain clearly detectable (59).”
• Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides1 (2002, background): “Similarly, it has been described that monocyte-derived immature DCs down-regulate TLR4 upon maturation with the corresponding cognate ligand LPS, but also in response to the unrelated maturation stimulus TNF (35).”
• TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes1 (2005, background): “The variable levels of TLR expression among individual donors may reflect a range of past environmental influences in a manner akin to the variation observable in human peripheral immune cells (20).”
• Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4 (2002, methodology): “for TLR-2 were used as described previously (27): 5 -TAT-”
• Innate Immunity to Mycobacterium tuberculosis (2002, background): “recognition on macrophages and dendritic cells (20, 135, 240).”