Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.

By J. Kyriakis, J. Avruch. Physiological Reviews, 2001

3,462 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1dcaa7374083197abf8a30199679a7a118662cdd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Philippe P Roux
2. Walter Kolch
3. R. Weinberg
4. K. Griendling
5. R. Davis
6. J. Blenis
7. Bozena Kaminska

In Molecular Biology

1. R. Seger
2. M. Valko
3. J. Blenis
4. Walter Kolch
5. Philippe P Roux
6. T. Force
7. Yibin Wang
8. B. Rose

Citations in the corpus

• The signals and pathways activating cellular senescence. (2005, background): “The stress-activated protein kinase family (SAPK) is a group of kinases that respond to a variety of physiologic stresses, including oxidative stress, and induce apoptosis and senescence in response (Kyriakis & Avruch, 2001).”
• GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4‐independent IFNγ production in T cells (2004, background): “…and other stimuli. p38 and JNK are activated via signaling cascades involving a MAPK kinase (MAPKK) that is responsible for phosphorylation of the appropriate MAPK, and a MAPK kinase kinase (MAPKKK or MAP3K) that phosphorylates and activates MAPKK (Davis, 2000; Kyriakis and Avruch, 2001).”
• p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases (2003, background): “MAP2K6 is activated by several MAPKKKs, which are activated by a wide variety of stimul”
• Controlling gene expression in response to stress (2011, background): “For example, the SAPKs in mammals are the p38 mitogen-activated protein kinase (MAPK) family (which contains four isoforms, MAPK11–14); these signalling pathways are activated by a variety of environmental (physical and chemical) stresses, such as heat shock, ultraviolet light, gamma rays, anisomyci”
• Drought and Salt Tolerance in Plants (2005, background): “G proteins and kinases in yeast and mammals have been shown to regulate MAPKKKs (Kyriakis and Avruch, 2001).”
• The inflammatory response in stroke. (2007, background): “p38 MAPK promotes the stabilization and enhanced translation of mRNAs encoding proinflammatory proteins (Kyriakis and Avruch, 2001).”
• The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “The p38 cascade is yet another SAPK pathway that exhibits a considerable cross-talk and shared components with the other stress-induced cascade of JNKs [43].”
• ROS and ROS-Mediated Cellular Signaling (2016, background): “Along with the pathways in which these four MAP kinases are activated share similarity by extracellular or intracellular stimuli, aMAPkinase kinase kinase (MAPKKK) is activated and then phosphorylating and activating a MAP kinase kinase (MAPKK) and the MAPKK phosphorylating and activating a MAP kina”
• MAP kinase signalling pathways in cancer (2007, background): “…six distinct groups of MAPKs have been characterized in mammals; extracellular signal-regulated kinase (ERK)1/2, ERK3/ 4, ERK5, ERK7/8, Jun N-terminal kinase (JNK)1/2/3 and the p38 isoforms a/b/g(ERK6)/d (Schaeffer and Weber, 1999; Chen et al., 2001b; Kyriakis and Avruch, 2001; Krens et al., 2006).”
• ERK/MAPK signalling pathway and tumorigenesis (2020, background): “…are mainly related to stress and apoptosis of cells, while the ERK/MAPK signalling pathway, which is the most thoroughly studied MAPK signalling pathway, is closely related to cell proliferation and differentiation and plays a pivotal role in the cell signal transduction network (11,28-30).”