Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

By B. K. Pedersen, M. Febbraio. Physiological Reviews, 2008

2,272 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/795c1a83f853edfba47628e63ce2d171fd0d2dd3

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Citations in the corpus

The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk (2009, background): “With regard to IL-6, its role in insulin resistance is highly controversial (as reviewed in Pedersen & Febbraio, 2008).”
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases (2015, background): “Thus, it is possible in theory for training to obstruct the new production of ovarian cysts (Pedersen & Febbraio, 2008).”
The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease (2011, background): “have focused on three possible mechanisms: the reduction in visceral fat mass; increased production and release of anti-inflammatory cytokines from contracting skeletal muscle (such molecules are termed myokine”
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis During Aging (2010, background): “In mammals, muscles produce a number of cytokines involved in the control of systemic metabolism (Nair, 2005; Pedersen and Febbraio, 2008).”
Muscles and their myokines (2011, background): “Thus, the health consequences of abdominal adiposity and physical inactivity are similar and both physical inactivity (Pedersen and Febbraio, 2008) and abdominal adiposity (Yudkin, 2007) are associated with persistent systemic low-grade inflammation (Festa et al., 2002; Handschin and Spiegelman,…”
Exercise is the real polypill. (2013, background): “Endogenous nitric oxide (NO), interaction between Ca(2) /nuclear factor of activated T-cell (NFAT), and glycogen/p38 MAPK pathways are putative upstream signals leading to muscleIL-6 secretion (368).”
FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine (2013, background): “As expected, both gastrocnemius and soleus tissues showed IL-6 secretion that significantly increased with exercise [19] (Figure 1A); on the other hand, we confirmed that subcutaneous adipose tissue secretes more adiponectin than visceral fat [20] and that this secretion significantly increased afte”
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise (2012, background): “If these hypotheses are confirmed, the role of irisin may prove to be no different than that of other myokines, such as IL-6, which increase immediately after exercise to regulate thermogenesis and metabolism but are negatively associated with metabolic variables in the long term [29].”