Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity.

By Guolong Zhang, S. Ghosh. Journal of Clinical Investigation, 2001

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK (2001, methodology): “To facilitate the identification of TRIKA2, we carried out immunoblotting analysis at each purification step using antibodies against proteins previously implicated in the IL-1 pathwa”
Bacterial direct-fed microbials in ruminant diets: Performance response and mode of action (2003, background): “Upon infection by an antigen via the oral route, immune cells are rapidly activated, leading to enhanced phagocytosis as well as the production of a vast array of humoral mediators (Zhang and Ghosh, 2001).”
The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS (2002, background): “(Means et al., 2000, 2001; Medzhitov and Janeway, 2000; Zhang and Ghosh, 2001), we next determined whether these receptors”
T Cell-Intrinsic Requirement for NF-κB Induction in Postdifferentiation IFN-γ Production and Clonal Expansion in a Th1 Response1 (2003, background): “These proteins comprise a family whose evolutionary roots are tightly linked to innate host defenses against pathogens, and are prototypic links in inflammatory responses to microbes (14, 15).”
Toll-like receptors modulate adult hippocampal neurogenesis (2007, background): “dtd" [ ]> Neurogenesis — the formation of new neurons in the adult brain — is considered to be one of the mechanisms by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic change”