Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

By E. Cario, D. Podolsky. Infection and Immunity, 2000

1,354 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/d2debc92db0ec15121e9064173b8c376623e3547

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Abreu
2. W. Strober
3. Shizuo Akira

In Immunology

1. Shizuo Akira
2. K. Takeda
3. R. Medzhitov
4. T. Kaisho
5. D. Underhill
6. A. Ozinsky
7. Misako Matsumoto
8. Tsukasa Seya

In Surgery

1. M. Abreu
2. Shizuo Akira

Citations in the corpus

• The immunological and genetic basis of inflammatory bowel disease (2003, background): “It is probable that this function of epithelial cells has an important role in mucosal host defence, and that they are also involved in the initiation and/or potentiation of mucosal inflammation and IB”
• TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction (2003, background): “As epithelial cells, peripheral blood leukocytes and DCs express TICAM-1 and TLR3 mRNA”
• The gut flora as a forgotten organ (2006, background): “In gastric epithelial cells, TLR5 can redistribute to a predominantly basolateral localization in response to Helicobacter pylori infection (Cario & Podolsky, 2000; Schmausser et al, 2004), suggesting that under certain conditions TLR5 redistributes to the basolateral membrane where it is ideally…”
• Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function (2010, methodology): “So, immunohistochemistry, enzymatic separation of IECs and laser capture microdissection of the intestinal epithelium were used to show that TLR2 and TLR4 are expressed at low levels by IECs in normal human colon tissue”
• Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines (2002, background): “Human intestinal epithelial cells constitutively express TLR3 and decrease its expression in Crohn’s disease but not in ulcerative colitis (35).”
• Toll-like receptors. (2003, background): “In contrast, intestinal epithelium from patients with inflammatory bowel diseases showed augmented expression of TLR4 (158).”
• TLR Signaling in the Gut in Health and Disease1 (2005, neutral): “TLR expression in commonly used human-derived IEC lines TLRs SW480 Caco2 T84 HT-29 1 RNA, protein (9) RNA (low level) (8) RNA (8) RNA (8) 2 * (9), (36) RNA, protein (92), RNA (5), poorly responsive to ligands (6, 8), RNA, ( protein) poorly responsive to ligands (8), protein (92) RNA, poorly responsi”
• A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species (2014, background): “Expression of TLR4 has been also detected in intestinal epithelial cell lines (69, 70).”