IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

By Liang Zhou, I. Ivanov, R. Spolski, Roy Min, K. Shenderov, Takeshi Egawa, D. Levy, W. Leonard, Dan R. Littman. 2007

2,242 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Pathology and Forensic Medicine

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Jetten
2. W. E. Paul
3. Jinfang Zhu
4. C. Dong
5. Dan R. Littman
6. G. Lee
7. V. Kuchroo
8. D. Artis

In Oncology

1. M. Karin
2. S. Grivennikov
3. J. O’Shea
4. Y. Kanno
5. M. Smyth
6. D. Sheppard
7. P. Murray
8. W. E. Paul

In Pathology and Forensic Medicine

1. M. Karin
2. M. V. D. van den Brink
3. T. Korn
4. D. Sheppard
5. W. E. Paul
6. C. Dong
7. Dan R. Littman
8. Jinfang Zhu

Citations in the corpus

• The Microbiome in Infectious Disease and Inflammation (2012, neutral): “In these mutant mice, LP macrophages are in the state of constitutive and aberrant activation, and the blockade of TLR signaling by introducing a deficiency in TLR4 or MyD88 abrogates this intestinal inflammation (92, 93), indicating that IL-10 acts on myeloid cells and induces STAT3 activation to s”
• Identification of IL-17-producing FOXP3+ regulatory T cells in humans (2009, background): “Signaling induced by these cytokines results in phosphorylation of STAT3 and expression of the orphan nuclear receptor ROR t, transcription factors that are required for induction of IL-17 expression (19, 20, 22).”
• IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism (2010, background): “Although there is uncertainty about the stringency of the requirement for IL-21 in the formation of Th17 in vivo (Coquet et al., 2008; Sonderegger et al., 2008), it is possible that this T cell subset may influence GC function, as IL-17 has been shown to influence GC B cell activity in at least one ”
• Differentiation of Effector CD4 T Cell Populations (2010, neutral): “IL-21 expression induced by the STAT3 pathway is independent of RORγt, but optimal IL-23R expression requires RORγt.”
• Innate and adaptive immunity in inflammatory bowel disease. (2014, background): “Th17 cells are induced by a combination of IL-6 and transforming growth factor (TGF)-β, and their expansion is promoted by IL-23 [70].”
• Th17 cells in human disease (2008, background): “It has recently been suggested that IL-21 is involved in the generation of Th17 cells in mice (34), and studies have shown that IL-21R expression is increased in keratinocytes from patients with systemic sclerosis (126).”
• Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. (2009, background): “We have shown that IL-1b and IL-23 can induce IL-17 and IL-21 expression in gd T cells, and it has already been reported that IL-21 together with TGF-b or IL-23 can stimulate IL-17 production by CD4+ T cells (Korn et al., 2007; Nurieva et al., 2007; Zhou et al., 2007).”
• T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. (2008, background): “, 2007) and in vivo (Zhou et al., 2007).”
• IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (2010, background): “…there was a 72% reduction in HEL3Xhi-binding GC B cells (P = 0.035) 10 d Th17 cell formation, it is possible that a role for IL-21 would become more apparent in IL-6–deficient mice (Korn et al., 2007; Nurieva et al., 2007; Zhou et al., 2007; Coquet et al., 2008; Sonderegger et al., 2008).”