T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.
By Xuexian O. Yang, B. Pappu, R. Nurieva, A. Akimzhanov, H. Kang, Yeonseok Chung, Li Ma, Bhavin Shah, Athanasia D. Panopoulos, K. Schluns and 4 more. Immunity, 2008
1,680 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/138cd03d1125d39e434db2dff388e09ad128e9a4
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In Immunology
Citations in the corpus
- An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis (2016, background): “Compared with controls, culturing with Collinsella led to more than a twofold increase in the expression of interleukin (IL)-17A as well as RORα and chemokines CXCL1 and CXCL5, which are known to regulate production of IL-17 [30, 31].”
- The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “Furthermore, activation of STAT3 (Mathur et al., 2007; Yang et al., 2007), as well as involvement of the orphan nuclear receptor RORa (Yang et al., 2008b) and of the aryl hydrocarbon receptor (Quintana et al., 2008; Veldhoen et al., 2008) have been suggested to be important in Th17 development.”
- TH17 cells in development: an updated view of their molecular identity and genetic programming (2008, background): “Importantly, STAT3 deficiency markedly decreased the expression of RORγt and RORα, which are now known to be lineage-specific transcription factors for T H 17 cell”
- Epigenetic control of T-helper-cell differentiation (2009, background): “This results in an increase in the expression of RORγt (as well as of RORα, which has an ancillary role in T H 17-cell induction”
- The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt (2008, background): “This result does not rule out the possibility of a small contribution in directing IL-17 expression by the closely related paralog RORα, which has a similar function in mic”