Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

By Donna D. Zhang. Drug metabolism reviews (Softcover ed.), 2006

1,068 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/47d91b2e3f036bb6d8f332037fdfbba448d3c678

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Citations in the corpus

The Dual Roles of NRF2 in Cancer. (2016, background): “Upon cell exposure to oxidative stress, NRF2 translocates to the nucleus, forms a heterodimer with its partner sMAF (vMaf avian musculoaponeurotic fibrosarcoma oncogene homolog), and binds to ARE (antioxidant responsive element) sequences to regulate the transcription of several types of genes [13] ”
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. (2009, background): “…of an intracellular antioxidant response through transcriptional activation of an array of genes, including phase II detoxifying enzymes, antioxidants, and transporters that protect cells from toxic and carcinogenic chemicals (Kensler et al., 2007; Kobayashi and Yamamoto, 2005; Zhang, 2006).”
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62 (2010, background): “Under basal conditions, Nrf2 levels remain relatively low; however, a plethora of inducers, which include phytoantioxidants and oxidative stress conditions, can induce Nrf2 protein levels and activate the pathway (9, 27).”
The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “The major transcription factor that regulates GSH metabolism is the ubiquitously expressed protein NF-E2-related factor 2 (Nrf2), a member of the Cap ’n’ Collar family of bZIP proteins [for reviews see (113, 296)].”
Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents (2012, background): “217 Other catechol-type antioxidant compounds, such as purpurogallin carboxylate175 (56), nordihydroguaiaretic acid175, 218 (57),160, 203 1,2-naphthoquinone (58),219 and its natural diterpene derivative tanshinone IIA (59),175 were also shown to activate Nrf2 and upregulate some of the Nrf2s downstr”
Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. (2008, background): “In addition to serving as an inhibitor, Keap1 can function as a sensor of oxidants and electrophiles, which react with its redoxsensitive cysteine residues (Zhang, 2006).”
Nrf2:INrf2(Keap1) Signaling in Oxidative Stress (2009, background): “Nrf2 was subsequently shown to be involved in the transcriptional activation of other ARE-responsive genes such as GST Ya, γ-GCS, HO-1, antioxidants, proteasomes, and drug transporters [3,6–9,28–33].”
Molecular Mechanisms of Nrf2-Mediated Antioxidant Response (2009, background): “implied in the etiology of diverse diseases, including cancer [4,5].”
Reactive Oxygen Species in Health and Disease (2012, background): “As previously mentioned, activated Nrf2 will be translocated to the nucleus to increase the rate of expression of a group of antioxidant and oxidantdetoxifying genes [39, 40].”
TOXICITY TESTING IN THE 21ST CENTURY: A VISION AND A STRATEGY (2010, background): “, 2006a), and a preliminary Nrf2 oxidativestress model has been developed (Zhang, 2006) to examine chlorine as an oxidative”
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. (2008, background): “The transcription factor NF-E2-related factor 2 (Nrf2) was originally identified to be a critical regulator of intracellular antioxidants and phase II detoxification enzymes by the transcriptional upregulation of many ARE-containing genes ( 1 ,2).”
Trends in oxidative aging theories. (2007, neutral): “Potential examples includes FOXO3a [357], p66SHC [245], Nrf2ARE [358], and most recently, p53 [329].”
From endoplasmic-reticulum stress to the inflammatory response (2008, background): “After PERK-mediated phosphorylation, NRF2 translocates to the nucleus and activates the transcription of a set of antioxidant and oxidant-detoxifying enzymes, including NAD(P)H–quinone oxidoreductase, haem oxygenase 1 and glutathione S -transferas”