Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response.

By Weimin Chen, Zheng Sun, Xiao-jun Wang, T. Jiang, Zheping Huang, Deyu Fang, Donna D. Zhang. Molecules and Cells, 2009

624 citations recorded by the source corpus.

Subfields: Molecular Biology, Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/21f9de894d2228310288b3696e1f893cf5760e7d

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Citations in the corpus

When NRF2 Talks, Who's Listening? (2010, positive): “p21 blocks the cell cycle by stopping progression through the G1=S checkpoint (30, 45, 160), and allows the stabilization of NRF2 and an increased level of detoxification enzymes (19).”
Oxidative stress response and Nrf2 signaling in aging. (2015, positive): “motifs in Nrf2, the same motifs bound by KEAP1, Nrf2- KEAP1 interaction is reduced, so as KEAP1-mediated Nrf2 degradation, in other words, Nrf2 level and Nrf2/EpRE signaling is increased [281].”
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution (2011, background): “For instance, the C-terminal region of p21Cip1 ⁄ WAF1p21 is shown to associate with the DLG motif of Nrf2 (Chen et al. 2009), and this makes the latch (DLG site) open and turn off the E3 ligase activity of Keap1 (Fig.”
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62 (2010, background): “We showed that the interaction of p21 with Nrf2 disrupted the binding of Nrf2 to the E3 ubiquitin ligase complex and prevented Keap1-dependent ubiquitination and degradation of Nrf2 (2).”
How Do Nutritional Antioxidants Really Work: Nucleophilic Tone and Para-Hormesis Versus Free Radical Scavenging in vivo (2013, positive): “Furthermore p21 increases the stability of Nrf2 [114] while c-Myc apparently accelerates Nrf2 degradation and inhibits Nrf2-dependent transcription by binding to it at EpREs [115].”
The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. (2013, background): “3) which binds with Nrf2 at the DLG and ETGE motifs through its C-terminal KRR motif to stabilize Nrf2 and thus confer protection against oxidative stress however the exact mechanism remains to be elucidated [112].”