Trends in oxidative aging theories.

By F. Muller, M. Lustgarten, Y. Jang, Arlan Richardson, H. Van Remmen. Free Radical Biology & Medicine, 2007

1,089 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/27d1755a34b95561469385ef6ed7f06a392bdb4e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. M. Brand
2. Nicholas A. Bishop
3. Tao Lu
4. D. Slade
5. M. Radman
6. B. Yankner

In Molecular Biology

1. M. Brand
2. K. Spriggs
3. Qitao Ran
4. Anne E. Willis
5. M. Bushell
6. D. Slade
7. M. Radman
8. Navdeep S. Chandel

In Physiology

1. M. Brand
2. Nicholas A. Bishop
3. Tao Lu
4. D. Slade
5. M. Radman
6. B. Yankner
7. J. Speakman

Citations in the corpus

• Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease (2019, background): “Double gene deletion combinations of SOD1 alongside another antioxidant gene resulted in reduced life expectancy of mice [133, 137].”
• Is the Oxidative Stress Theory of Aging Dead? (2009, background): “, deletion in CuZnSOD resulted in 80% reduction in lifespan [71,72]; deletion in Sod2 induced postnatal lethality [73,74]; Drosophila heterozygous for the SOD1 gene show no significant differences, and SOD2 gene show a slight reduction in lifespan [71,74,75].”
• Oxidative Stress Resistance in Deinococcus radiodurans (2011, background): “To date, various attempts to decelerate aging, cancer, and other conditions with oxidative stress phenomenology by administering antioxidant therapy (58, 476, 638), or even genetically overexpressing antioxidant activities (337, 449, 488), have failed to show any benefit with respect to disease outc”
• Translational regulation of gene expression during conditions of cell stress. (2010, background): “The translational reprogramming following nutrient depletion would have the net effect of inducing the cellular level of reactive oxygen species (ROS) and inducing oxidative stress, amajor cause of molecular damage that is associated with aging (Muller et al., 2007).”
• Competing interests (2010, neutral): “In fact, it is well-known that free radical formation during cellular growth hinders cell proliferation [44] and that GNPs act as antioxidants to overcome such problems [31,45–47].”
• The sites and topology of mitochondrial superoxide production (2010, background): “An association between mitochondrial ROS generation and age-related disease is generally accepted, although it is also agreed that the mitochondrial free radical theory's explanation of ageing is incomplete (Beckman and Ames, 1998; Finkel and Holbrook, 2000; Golden et al., 2002; Muller et al., 2007;”
• Oxidative Stress in Aging Human Skin (2015, background): “However, before the electrons reach complex IV they can leak prematurely to O2 at complex I and III, leading to the formation of superoxide instead of water [2,77,78].”
• Neural mechanisms of ageing and cognitive decline (2010, background): “Oxidative stress and epigenetic changes Multiple lines of evidence suggest that progressive oxidative damage is a conserved, central mechanism of age-related functional declin”
• Antioxidative activity of lactic acid bacteria in yogurt (2011, background): “According to the free radical theory of aging (Muller et al., 2007), the disruption of the delicate balance between generation of reactive oxygen species (ROS) and antioxidant scavenging systems with increasing age could lead to a shift to an oxidative cellular milieu, and eventually lead to…”
• Redox Regulation of Cell Survival (2008, neutral): “This may be caused by progressive senescence of postmitotic tissues, likely due to chronic damage by ROS (218).”