The Dual Roles of NRF2 in Cancer.
By Silvia Menegon, A. Columbano, S. Giordano. Trends in Molecular Medicine, 2016
742 citations recorded by the source corpus.
NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective functions are deemed to be the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress. However, several recent studies demonstrate that hyperactivation of the NRF2 pathway creates an environment that favors the survival of normal as well as malignant cells, protecting them against oxidative stress, chemotherapeutic agents, and radiotherapy. In a rapidly advancing field, this review summarizes some of the known mechanisms by which NRF2 can exert its oncogenic functions, and describes the current status of NRF2 inhibitors, providing a clear rationale for the consideration of NRF2 as a powerful putative therapeutic target in cancer treatment.
Subfields: Molecular Biology, Organic Chemistry, Plant Science
View Paper: https://www.semanticscholar.org/paper/69d5843be946cc6eb4ba13e93f16a5ff9ebe277d
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Citations in the corpus
- Combination therapy in combating cancer (2017, background): “For example, Nrf2 was upregulated in hepatocellular carcinoma, and in the same study it was shown that Nrf2 positively regulates GSTP1 (an enzyme that has a role in detoxification) [38].”
- p62 links autophagy and Nrf2 signaling. (2015, background): “Furthermore, Nrf2 has proven to contribute to chemoresistance [17,58].”