Reactive Oxygen Species in Health and Disease
By A. Alfadda, Reem M. Sallam. Journal of Biomedicine and Biotechnology, 2012
867 citations recorded by the source corpus.
During the past decades, it became obvious that reactive oxygen species (ROS) exert a multitude of biological effects covering a wide spectrum that ranges from physiological regulatory functions to damaging alterations participating in the pathogenesis of increasing number of diseases. This review summarizes the key roles played by the ROS in both health and disease. ROS are metabolic products arising from various cells; two cellular organelles are intimately involved in their production and metabolism, namely, the endoplasmic reticulum and the mitochondria. Updates on research that tremendously aided in confirming the fundamental roles of both organelles in redox regulation will be discussed as well. Although not comprehensive, this review will provide brief perspective on some of the current research conducted in this area for better understanding of the ROS actions in various conditions of health and disease.
Subfields: Molecular Biology, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/bb5df9f027664007cecb19a42ed6cc9d6de7fafb
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Citations in the corpus
- Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety (2019, background): “Moderate exposure to ROS is necessary to induce adaptive antioxidant defense mechanisms, however, chronic or high levels of exposure have been linked to disease conditions and signaling the blood coagulation system (Alfadda and Sallam, 2012; He et al., 2016).”
- ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “As such, the disturbance of cellular redox balance is a risk factor for the development of various pathologies [2].”
- Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution (2024, background): “As a consequence, ROS participate in various pathological processes in almost all aerobes [8].”
- Biochemistry of Reactive Oxygen and Nitrogen Species (2015, background): “ROS produced by other pathways, including the respiratory burst taking place in activated phagocytes, are ionizing the damaging effect of the radiation on components of cell membranes, and by-products of several cellular enzymes (NADPH oxidases, xanthine oxidase, nitric oxide synthase) [23].”
- The role of oxidative stress during inflammatory processes (2013, background): “The oxidative chemistry of peroxynitrite depends in large part on the secondary formation of free radicals (Figure 1), including the hydroxyl radical (.”