The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

By Jana Lewerenz, S. Hewett, Ying Huang, M. Lambros, P. Gout, Peter W. Kalivas, A. Massie, I. Smolders, A. Methner, Mathias Pergande and 3 more. Antioxidants and Redox Signaling, 2013

914 citations recorded by the source corpus.

Subfields: Biochemistry, Oncology

View Paper: https://www.semanticscholar.org/paper/9018576e5023454ea3cba345b708c4d405ab2b4e

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In Biochemistry

1. Yun Zhou
2. Pranavi Koppula
3. B. Gan
4. Zhuang Li
5. N. Danbolt

Citations in the corpus

• Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer (2018, background): “Various compounds and drugs have been identified to block the transport activity of SLC7A11 [9], among which the most prominent example is sulfasalazine, an FDA-approved drug commonly used to treat chronic inflammatory diseases such as rheumatoid arthritis [74].”
• Glutamate as a neurotransmitter in the healthy brain (2014, background): “There are several reasons why xCT has become a hot topic (Conrad and Sato 2012; Lewerenz et al. 2013; Bridges et al. 2012a, b).”