Nuclear Export of MicroRNA Precursors

By E. Lund, Stephan Güttinger, Â. Calado, J. Dahlberg, U. Kutay. Science, 2004

2,856 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/45803a2386946716508fb9091a723d21474bbeb7

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Citations in the corpus

Small RNA sorting: matchmaking for Argonautes (2010, background): “The nuclear export protein Exportin 5 recognizes the 2-nt single-stranded 3′ overhang of the pre-miRNA (characteristic of RNase III-mediated cleavage) and actively transports it in a Ran–GTP-dependent manner to the cytoplas”
MicroRNAS and their regulatory roles in plants. (2006, background): “from the nucleus to the cytoplasm (82, 146).”
Human MicroRNA Targets (2004, background): “The premiRNA is subsequently transported across the nuclear membrane, dependent on the protein exportin 5 (Lund et al. 2003; Yi et al. 2003).”
Metazoan MicroRNAs (2018, background): “After export to the cytoplasm through the action of Exportin 5 and RAN–GTP (Yi et al., 2003; Bohnsack et al., 2004; Lund et al., 2004), the pre-miRNA is further processed by Dicer (Grishok et al.”
MicroRNAs in cell proliferation, cell death, and tumorigenesis (2006, background): “Pre-miRNAs are rapidly exported to the cytoplasm by the nuclear export factor exportin 5 which uses Ran-GTP as a cofactor (Yi et al, 2003; Bohnsack et al, 2004; Lund et al, 2004).”
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. (2009, background): “Pre-miRNA is exported to the cytoplasm by exportin 5 (Bohnsack et al., 2004; Lund et al., 2004; Yi et al., 2003) and gets further processed into a mature miRNA of 22 nt by another RNase III, Dicer (Bernstein et al., 2001; Grishok et al., 2001; Hutvagner et al., 2001; Ketting et al., 2001; Knight…”
The role of PACT in the RNA silencing pathway (2006, background): “Pre-miRNAs are then exported to the cytoplasm with the help of exportin-5 (Exp5) (Yi et al, 2003; Bohnsack et al, 2004; Lund et al, 2004) and subsequently processed into mature miRNA of B22 nt by another RNase III Dicer (Grishok et al, 2001; Hutvagner et al, 2001).”
microRNAs as oncogenes and tumor suppressors. (2007, background): “The pre-miRNAs are then transported to the cytoplasm by Exportin-5 (Exp5) (a member of the Ran transport receptor family) (Bohnsack et al., 2004; Lund et al., 2004; Yi et al., 2003).”
The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. (2004, background): “HST encodes a protein that is homologous to Exportin-5, and hst mutants have developmental phenotypes, suggesting that HST participates in the transport of miRNAs or pre-miRNAs from the nucleus to the cytoplasm (Bollman et al. 2003; Yi et al. 2003; Bohnsack et al. 2004; Lund et al. 2004).”
Illuminating the silence: understanding the structure and function of small RNAs (2007, background): “To assemble into RISCs and to silence genes, pre-miRNAs have to be moved to the cytoplasm by a nuclear transport receptor complex, exportin-5 –RanGT”
Tools for Sequence-Based miRNA Target Prediction: What to Choose? (2016, background): “The pre-miRNA is then exported from the nucleus to the cytoplasm by Exportin 5 [36], where this pre-miRNA can be degraded or processed by DICER1, another RNase III enzyme.”
The Drosha-DGCR8 complex in primary microRNA processing. (2004, background): “This initial processing event predetermines mature miRNA sequences by generating one end of mature miRNA (Lee et al. 2003; Lund et al. 2004).”
Genetic variation in microRNA networks: the implications for cancer research (2010, positive): “XPO5 is responsible for miRNA nuclear export, and knocking down its expression leads to reduced miRNA level”
Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha (2005, background): “The pre-miRNA is then exported to the cytoplasm by the nuclear export factor Exportin 5 and the Ran-GTP cofactor (Yi et al, 2003; Bohnsack et al, 2004; Lund et al, 2004).”