TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.

By Inha Heo, Chirlmin Joo, Young‐Kook Kim, Minju Ha, Mi-Jeong Yoon, Jun Cho, Kyu-Hyeon Yeom, Jinju Han, V. Narry Kim. Cell, 2009

839 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b1d80136d9f0e0c847445007c7186e4736af1459

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Citations in the corpus

The long and short of microRNA. (2013, background): “It is therefore possible that ZCCHC6/ ZCCHC11 recruitment to pre-let-7 in part depends on induction of long-range conformational changes in the dsRNA stem (Thornton et al., 2012).”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “After transport into the cytoplasm, post-transcriptional modifications of some pre-miRNAs are catalysed by terminal uridylyltransferase 4 ( TUT4 ), which has been shown to be recruited by LIN28 to mediate uridylation of pre-let-7 miRN”
microRNAs in action: biogenesis, function and regulation (2023, background): “118,119), which triggers its degradation via Dis3L2 (refs.”
An overview of microRNAs (2015, background): “enzyme Tut4 to add an oligouridine tail to let-7 precursors, marking them for degradation[131-134].”
MicroRNA control of signal transduction (2010, background): “Following the binding to pre-let-7, lIN-28 induces 3′ terminal uridylation and subsequent degradation of let-7 by recruiting a terminal ribonucleotransferase or poly(U) polymerase, such as terminal uridylyltransferase 4 (Ref”
Metazoan MicroRNAs (2018, background): “Lin28 binds to the terminal loop of let-7 pre-RNAs, which promotes oligo(U)-tailing at the 3′ end of these pre-miRNAs, through the recruitment of terminal uridylyl transferases, TUT4 and TUT7 (Heo et al., 2008; Hagan et al., 2009; Heo et al., 2009; Nam et al., 2011).”
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. (2010, background): “TUT4-catalyzed poly(U) addition to the let-7 premiRNA , which is specified by Lin28, plays an important role in post-transcriptional repression of let-7 expression (Heo et al. 2008, 2009; Hagan et al. 2009).”
Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs (2010, background): “Today we know more about alternative processing of the primary miRNA transcripts (pri-miRNAs) in a Droshaindependent fashion (26,27) and regulation of the microprocessor complex itself (25,28,29).”