Requirement for RORgamma in thymocyte survival and lymphoid organ development.

By Zuoming Sun, D. Unutmaz, Y. Zou, M. Sunshine, A. Pierani, Susan Brenner-Morton, R. Mebius, Dan R. Littman. Science, 2000

814 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/4479537af41fbbe06267fdd9279c278803a6afc1

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In Immunology

Citations in the corpus

Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. (2007, background): “RORγt was initially identified in the thymus and is required for the expression of the antiapoptotic protein Bcl-xL, which promotes the survival of CD4/CD8 double-positive thymocytes (30).”
Identification of IL-17-producing FOXP3+ regulatory T cells in humans (2009, background): “In the mouse, the nuclear receptor ROR t is expressed in CD4 CD8 thymocytes but not in single-positive CD4 or CD8 thymocytes (39).”
RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells (2009, background): “RORγt is required for the development of lymphoid tissue–inducer cells (LTi cells), and mice lacking RORγt fail to develop lymph nodes and cryptopatche”
Interleukin-22: immunobiology and pathology (2015, background): “lympohoid tissues (MALT), including lymph nodes, cryptopatches, isolated lymphoid follicles (ILFs), and Peyer’s patches (79, 80, 82, 83, 86, 88).”
An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells (2004, background): “18 ) or the retinoic acid–related orphan receptors (RORs) RORγ and RORγ”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…that then colonize the secondary lymphoid organs, including the spleen, lymph nodes, and PPs. RORγt is transiently expressed during thymopoiesis [Guo et al., 2002; He, 2002; He et al., 2000; He et al., 1998; Jetten, 2004; Jetten and Joo, 2006; Jetten et al., 2001; Sun et al., 2000] (Figure 5).”
Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes (2002, background): “Mice that lack, due to a deletion of the shared DNA-binding domain, both RORγ and RORγt (which are referred to hereafter as RORγ −/− mice) show increased programmed cell death of DP thymocyte”
CD4+ lymphoid tissue inducer cells promote innate immunity in the gut (2010, background): “…cells (defined as Lin c-kit+CD4+CD44+CD127+CD25+ CD90+CCR6+) is dependent on the transcription factors RORgt and Id-2, and IL-7 has been shown to regulate their survival and function (Eberl et al., 2004; Mebius, 2003; Mebius et al., 1997; Meier et al., 2007; Sun et al., 2000; Yokota et al., 1999).”
Differentiation of Effector CD4 T Cell Populations (2010, neutral): “RORγt is also expressed in double-positive (DP) thymocytes (92) and other cell types including lymphoid tissue inducer (LTi) cells, where IL-17 is also produced (93).”