Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes

By Jian Guo, A. Hawwari, Hong Li, Zuoming Sun, S. Mahanta, Dan R. Littman, M. Krangel, You-Wen He. Nature Immunology, 2002

192 citations recorded by the source corpus.

Subfields: Immunology

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Raising the NKT cell family (2010, background): “The DNA excision circles are limited in size, and the expression of distal (3′) segments that require multiple excisions is dependent on an extended lifespan of DP thymocyte”
Origin and evolution of the adaptive immune system: genetic events and selective pressures (2010, background): “The many J segments in the α locus allow extensive receptor editing in developing T cells, resulting in greater opportunities for modification of the antigen receptor, followed by potential selection of self-MHC-restricted TCRs in the thymu”
An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells (2004, result): “5 fetuses, in contrast to earlier findings based on the detection of Rorc (γt) mRN”
Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T‐cell receptor α/δ locus (2004, background): “Analysis of TCRa rearrangements in fetal thymocytes and in early DP thymocytes of adult mice demonstrates a strong 50 bias to Ja usage (7, 25, 40) (Fig.”