Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation.

By R. Kastelein, Christopher A. Hunter, D. Cua. Annual Review of Immunology, 2007

825 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/e8683ed5279f95af00491def9a410b7efa70a189

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. V. Kuchroo
2. T. Korn
3. M. Oukka
4. M. V. D. van den Brink
5. A. Di Cesare
6. Frank O. Nestle
7. Y. Iwakura
8. P. Di Meglio

In Oncology

1. V. Kuchroo
2. Shizuo Akira
3. Taro Kawai

In Pathology and Forensic Medicine

1. M. V. D. van den Brink
2. T. Korn
3. Y. Iwakura
4. E. Bettelli
5. M. Oukka
6. V. Kuchroo
7. J. Dudakov
8. A. Hanash

Citations in the corpus

• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “IL-23 primarily targets immune cells (Kastelein et al., 2007).”
• Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens (2008, neutral): “Although IL-23 has very diverse proinflammatory function”
• Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis (2011, methodology): “Peripheral T cell blasts from a patient displayed normal STAT3 activation in response to IL-23, as shown by WB (Fig.”
• The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “Furthermore, the development and maintenance of Th17 cells have been linked to IL-23, a key initiating cytokine in the development of autoimmunity (Bettelli et al., 2007; Kastelein et al., 2007).”
• Interleukin-22: immunobiology and pathology (2015, background): “Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M. Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.”
• Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, background): “IL-17A is a proinflammatory cytokine produced by Th17 cells (Iwakura et al., 2008; Kastelein et al., 2007).”