The Hedgehog and Wnt signalling pathways in cancer

By Jussi Taipale, P. Beachy. 2001

1,479 citations recorded by the source corpus.

Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. P. Beachy
2. R. Nusse
3. Jussi Taipale
4. C. Blanpain
5. Andrew P. McMahon
6. M. Clarke
7. R. DePinho
8. Elaine Fuchs

In Pediatrics, Perinatology and Child Health

1. R. Nusse
2. M. Clarke
3. James E. Darnell
4. P. Ingham
5. P. Beachy
6. Jussi Taipale
7. S. Baylin

Citations in the corpus

• Tissue repair and stem cell renewal in carcinogenesis (2004, background): “Stem cells are appealing candidates as the ‘cell of origin’ for cancer because of their pre-existing capacity for self-renewal and unlimited replicatio”
• Epidermal stem cells of the skin. (2006, background): “Similar to Wnt/β-catenin, Shh is an ancient signaling pathway involved in cell fate specification and proliferation during animal development (Taipale & Beachy 2001).”
• Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “In addition, EGF also induces the expression of SNAI1 and TWIST, leading to repression of the CDH1 promoter (153).”
• Mechanisms and functions of Hedgehog signalling across the metazoa (2011, background): “Diversification of HH function and deployment HHsignalling has a multitude of functions in embryonic and adult tissues: it acts as a key mediator of fundamental processes, such as cell fate specification, proliferation and patterning, as well tissue morphogenesis and homeostasis — roles that have ”
• RTCGD: retroviral tagged cancer gene database (2004, background): “While the Wnt signaling pathway has been associated with other human cancers, including colorectal cancer, desmoid tumors and hepatoblastomas (21), it has not yet been causally associated with human hematopoietic disease.”
• Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours (2003, background): “Patched (PTCH, the target of Gorlin's syndrome mutations) to restrain Smoothened (SMO)-mediated activation of transcriptional targets through the Gli family of latent transcription factor”
• Patched acts catalytically to suppress the activity of Smoothened (2002, background): “jpg" NDATA ITEM> ]> Mutations affecting the transmembrane proteins Patched (Ptc) or Smoothened (Smo) that trigger ligand-independent activity of the Hedgehog (Hh) signalling pathway are associated with human tumours such as basal cell carcinoma (BCC) and medulloblastom”
• Hedgehog: functions and mechanisms. (2008, background): “Despite the conservation of the Hh signaling pathway and many of its roles in development between invertebrate and vertebrate species (Ingham and McMahon 2001; Taipale and Beachy 2001), the mechanisms by which Smo regulates the Ci/GLI transcription factors appears to be distinct between Drosophila a”
• E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer (2009, background): “of these target genes give the competence to act as a stem cell [75].”