Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

By Michael T. Lin, M. Beal. Nature, 2006

6,263 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/3e4c29d0b51f0ce49b6720e24eff2374cd1b156d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Peter F Surai
2. E. K. Kim
3. E. Choi
4. M. Beal
5. Xiongwei Zhu
6. G. Perkins
7. Xinglong Wang
8. M. H. Yan

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Peter Vandenabeele
4. Peter F Surai
5. Mónika Fuxreiter
6. P. Reddy
7. F. Pietrocola
8. A. Abramov

In Physiology

1. Johan Auwerx
2. C. Cantó
3. R. Houtkooper
4. Guido Kroemer
5. Peter F Surai
6. L. Galluzzi
7. A. Abramov
8. S. Gandhi

Citations in the corpus

• Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells (2012, methodology): “(c) HeLa cells were transfected with (Flag)N-Fundc1(1-155)-C(Myc) or (Flag)N-Fundc1(1-139)C(Myc) vectors, respectively.”
• Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways (2008, positive): “Isocitrate dehydrogenase 2 is an important enzyme in the control of mitochondrial redox balance and its decreased expression could be an important contributor to the oxidative stress that is observed in AD [27, 41].”
• Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. (2008, background): “3) [21,50] and in components of the tricarboxylic acid cycle, including αketoglutarate dehydrogenase [11,21].”
• The Role of Oxidative Stress in Neurodegenerative Diseases (2015, background): “findings that the Complex I inhibitors, such as 1-methyl-4-phenyl1,2,3,4-tetrahydropyridine (MPTP) and its metabolite, 1-methyl4-phenylpyridinium (MPP+), may exert cytotoxic effects on the DA neurons, resultong in clinically parkinsonian phenotype, and induce nigral degeneration with cytoplasmic α-s”
• Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration (2015, positive): “…Mus musculus Introduction Many neurodegenerative diseases are characterized by a gradual demise of neurons, coupled with a reduction in antioxidative capacity and/or an increase in oxidative stress (Turner et al., 2009; Gilgun-Sherki et al., 2001; Lin and Beal, 2006; Keller et al., 2005).”
• The Role of Oxidative Stress in Parkinson’s Disease (2013, neutral): “pathological and clinical features [18] suggesting that”
• Regulation of cancer cell metabolism (2011, background): “Mutations in SOD1 are responsible for 20% of familial cases of amyotrophic lateral sclerosis (ALS”
• Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “Oxidative stress is thought to be a key risk factor in the development of AD [28,29].”