Regulation of cancer cell metabolism

By R. Cairns, I. Harris, T. Mak. Nature Reviews. Cancer, 2011

4,678 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9d36b5b10983f1aa90a9d9d5a7bcffe671b38257

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

ROS homeostasis and metabolism: a dangerous liason in cancer cells (2016, background): “enzyme-catalyzed reactions culminating in the generation of pyruvate, adenosine tris-phosphate (ATP) and reduced cofactors in the form of NADH.(71) As already observed by”
Anoikis molecular pathways and its role in cancer progression. (2013, background): “take through PI3K/Akt pathway activation, quench ROS increasing NADPH production, rescuing cells from anoikis [35,189].”
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “One can envision the possibility that growing mammalian cells, including cancer cells, could also in some circumstances need ribose 5-phosphate in excess of NADPH, i.e. when DNA and RNA nucleotide synthesis is maximized (Ferreira, 2010; Cairns et al., 2011).”
Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, background): “Knockdown of ME1 significantly lowers cellular NADPH/NADP+ in conjunction with clonogenic survival of pancreatic ductal adenocarcinoma cells (64, 90).”
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells (2013, background): “Cancer cells appear to commonly acquire aberrancies in energy metabolism and cellular redox state (Cairns et al., 2011).”
Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. (2014, background): “Both of these processes promote rapid tumor cell growth (Cairns et al., 2011).”