The Role of Oxidative Stress in Neurodegenerative Diseases
By Geon Ha Kim, Jieun E. Kim, S. Rhie, Sujung Yoon. Experimental Neurobiology, 2015
1,327 citations recorded by the source corpus.
Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs especially vulnerable to the effects of ROS because of its high oxygen demand and its abundance of peroxidation-susceptible lipid cells. Previous studies have demonstrated that oxidative stress plays a central role in a common pathophysiology of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases, although the results with regard to their efficacy of treating neurodegenerative disease have been inconsistent. In this review, we will discuss the role of oxidative stress in the pathophysiology of neurodegenerative diseases and in vivo measurement of an index of damage by oxidative stress. Moreover, the present knowledge on antioxidant in the treatment of neurodegenerative diseases and future directions will be outlined.
Subfields: Biochemistry, Molecular Biology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/23a337be860734cb1666334d2f3dda598d27f551
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Citations in the corpus
- An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases (2022, background): “dehydrogenase, and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) [13,15].”
- Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016, background): “Evidence indicates that, through production of reactive oxygen species, oxidative stress acts as vehicle for deposition and accumulation of amyloid β (Aβ) in AD (Kim et al., 2015).”
- Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications (2017, background): “Presumably, there is more than one type of ROS involved in the pathophysiology of disease progression [30, 72].”