Pathological roles of MAPK signaling pathways in human diseases.

By E. K. Kim, E. Choi. Biochimica et Biophysica Acta, 2010

2,420 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/4db5351c505f3152c36bdb0e8ea1475bf295e59a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Roskoski
2. M. Bahar
3. D. Kim
4. Hyun Joon Kim
5. R. Seger
6. Qingxiang Zeng
7. Walter Kolch
8. Junjiang Liu

In Pharmacology

1. R. Seger
2. R. Roskoski

In Physiology

1. R. Roskoski

Citations in the corpus

• The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “It was also implicated in the induction and maintenance of neurodegenerative diseases [21], in diabetes [62], and even in cancer [63].”
• Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity (2020, background): “MAPK signaling is altered in many diseases [3] and its kinase components have, therefore, been in the crosshairs of drug development for the last two decades.”
• Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “Therefore, the MAPK pathway is divided into mitogen- and stress-activated MAPK pathways, with classical representatives being ERK as the mitogen-responsive MAPKs and JNK and p38 as the stress-responsive MAPKs.(156,157) Once the phosphorylation of ERK1/2, JNK1/2/3, or p38 is induced by an upstream ca”
• ERK1/2 MAP kinases: structure, function, and regulation. (2012, background): “The Ras-Raf-MEK-ERK signaling cascade is dysregulated in a ariety of diseases including brain injury, cancer, cardiac hyperrophy, diabetes, and inflammation [50–55].”
• Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies (2023, background): “50 Moreover, the RAS/ RAF/MAPK pathway is gaining attention as a potential target for the development of novel anti-in fl ammatory drugs, with implications for conditions like rheumatic arthritis (RA) 51 , in fl ammatory bowel disease (IBD) 52 and pulmonary fi brosis (PF).”
• Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways? (2011, background): “A number of extracellular and intracellular stimuli have been shown to activate MAPK pathways at cellular levels [3], implying that there may be tight and specific regulation of MAPK activation by a certain stimulus.”
• Inflammatory responses and inflammation-associated diseases in organs (2015, background): “MAPKKKs phosphorylate and activate MAPKKs, which in turn phosphorylate and activate MAPKs [33, 34].”