Regulation of wound healing by growth factors and cytokines.

By S. Werner, R. Grose. Physiological Reviews, 2003

3,662 citations recorded by the source corpus.

Subfields: Biomaterials, Orthopedics and Sports Medicine, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/3e404374679698732c97b09977f20f23b228a7eb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

In Orthopedics and Sports Medicine

In Rehabilitation

Citations in the corpus

Fibroblast growth factor signalling: from development to cancer (2010, background): “Initial studies showed a key role for FGF signalling in epithelial repair but some FGF members, in particular FGF2, are known to be important for new blood vessel growth at the wound site (reviewed in Ref”
Formation and function of the myofibroblast during tissue repair. (2007, background): “, 1993; Ronnov-Jessen and Petersen, 1993), ECM proteins (Werner and Grose, 2003), and a number of cytoskeletal proteins that construct the myofibroblast contractile apparatus (Malmstrom et al.”
Inflammation in Chronic Wounds (2016, background): “In response to mechanical tension and cytokines such as TGF-β, fibroblasts increase expression of α-smooth muscle actin, transforming into myofibroblasts, which contract the wound via their integrin receptor contacts to ECM components such as fibronectin and collagen [32,36].”
Skin Acute Wound Healing: A Comprehensive Review (2019, background): “Mature fibroblasts migrate into the granulation tissue, initiate collagen synthesis, replace the fibrin provisional matrix [41], and differentiate into myofibroblasts increasing collagen deposition and initiating wound contraction [38, 123].”
The myofibroblast: paradigm for a mechanically active cell. (2010, background): “It is intriguing that development of differentiated myofibroblasts is restricted to later phases of wound healing although blood platelets and inflammatory cells provide abundant active TGFb1 during the first days following injury (Blakytny et al., 2004; Werner and Grose, 2003).”
Origin and physiological roles of inflammation (2008, result): “This idea is in accordance with the fact that many inflammatory mediators (including TNF-α, IL-6, CCL2 and prostaglandins) also have important homeostatic functions, for example in repair of tissues, control of metabolism, and regulation of the hypothalamus–pituitary axi”
Cancer as an overhealing wound: an old hypothesis revisited (2008, background): “and members of the epidermal growth factor (EGF) famil”
Inflammation in wound repair: molecular and cellular mechanisms. (2007, background): “During the past decade numerous factors have been identified that are engaged in a complex reciprocal dialogue between epidermal and dermal cells to facilitate wound repair (Werner and Grose, 2003).”
Friends or foes — bipolar effects of the tumour stroma in cancer (2004, background): “These factors disrupt normal tissue homeostasis, similar to the processes of wound healin”
Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine (2012, background): “process via recruitment of multiple cell types including neutrophils, macrophages, fibroblasts, and other tissue specific cells to the injury site [91].”
Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration (2020, background): “The tissue repair process is controlled by the interaction of growth factors with specific cell surface receptors; these interactions stimulate cell migration, trigger angiogenesis, epithelialization, and encourage matrix formation and the remodeling of the injured site [61].”