Formation and function of the myofibroblast during tissue repair.

By B. Hinz. Journal of Investigative Dermatology, 2007

1,667 citations recorded by the source corpus.

Subfields: Orthopedics and Sports Medicine, Rehabilitation, Surgery

View Paper: https://www.semanticscholar.org/paper/c9965c78efc57d9bad52e1d623093aa3c94e42c5

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In Orthopedics and Sports Medicine

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Citations in the corpus

Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 1: Normal and Chronic Wounds: Biology, Causes, and Approaches to Care (2012, background): “Fibroblast-induced contractile forces are then transmitted to the ECM via cytoskeletonassociated and ECM receptorYdependent mechanocoupling focal adhesion complexes, that is, integrin receptors.(15) Another mechanism leading to wound contraction is fibroblast motility with consequent matrix reorgani”
The myofibroblast: paradigm for a mechanically active cell. (2010, background): “TGFb1 is the major cytokine inducing myofibroblast differentiation and binding of the TGFb receptor type II triggers a cascade of signaling events that ultimately lead to myofibroblast differentiation (Hinz, 2007).”
The myofibroblast matrix: implications for tissue repair and fibrosis (2013, positive): “However, subsequent studies seem to suggest that activating functions of CCN2 occur either up- or down-stream of TGF-β1 signalling since simultaneous blocking of TGF-β1 abolished their myofibroblast-activating effect [3,148].”
Pathophysiology of Myocardial Infarction (2015, neutral): “Cells that form stress fibers without incorporation of α-SMA (161,162) have been identified; whether these”
The Pathogenesis of Cardiac Fibrosis (2013, neutral): “Myofibroblasts are phenotypically modulated fibroblasts that accumulate in sites of injury and combine ultrastructural and phenotypic characteristics of smooth muscle cells, acquired through formation of contractile stress fibers, with an extensive endoplasmic reticulum, a feature of synthetically a”
Burn wound healing and treatment: review and advancements (2015, background): “Myofibroblasts adopt a contractile phenotype, and thus are involved in wound contracture [38].”
Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. (2008, background): “The differences between myofibroblasts and SMC are not well-defined [30]; furthermore, myofibroblasts are actively involved in the function of the vasculature as well as in pathologic processes, such as pulmonary, hepatic, and renal fibrosis [31–33].”
Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “Compared with quiescent fibroblasts, mature myofibroblasts adhere to ECM longer (Hinz, 2007), even in the presence of the same signals, suggesting that disengagement of focal adhesions may be essential for myofibroblast state termination (Thannickal, 2013).”
Macrophages are required for adult salamander limb regeneration (2013, background): “Disruption of collagen production in macrophage-depleted limb stumps is presumably due to the activation of myofibroblasts, which are mainly absent in normal axolotl limb and scar-free skin regeneration (31), contributes to scarring inmammals (50, 51), and represents a major difference between fibro”
Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “, TGF-b, drive fibroblasts to differentiate into myofibroblasts, which express a-smooth muscle actin (SMA) and contract the wound [44].”
Stromal myofibroblasts are drivers of invasive cancer growth (2008, background): “are essential for tissue morphogenesis, assist at stem cell niches and at mucosal immunity.(10,11) In cancer, a wound that does not heal,(12) myofibroblasts are either deficient or fullfil other functions such as the production of proinvasive proteinases.”
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “Identifying the origin of the myofibroblasts constitutes a chal- 204 Developmental Cell 21, August 16, 2011 ª2011 Elsevier Inc. lenge (Hinz, 2007).”