Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine
By B. Brown, B. Ratner, S. Goodman, S. Amar, S. Badylak. Biomaterials, 2012
870 citations recorded by the source corpus.
The host response to biomaterials has been studied for decades. Largely, the interaction of host immune cells, macrophages in particular, with implanted materials has been considered to be a precursor to granulation tissue formation, the classic foreign body reaction, and eventual encapsulation with associated negative impacts upon device functionality. However, more recently, it has been shown that macrophages, depending upon context dependent polarization profiles, are capable of affecting both detrimental and beneficial outcomes in a number of disease processes and in tissue remodeling following injury. Herein, the diverse roles played by macrophages in these processes are discussed in addition to the potential manipulation of macrophage effector mechanisms as a strategy for promoting site-appropriate and constructive tissue remodeling as opposed to deleterious persistent inflammation and scar tissue formation.
Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Surgery
View Paper: https://www.semanticscholar.org/paper/474b71afd0b396e78631b227727a1f33b936209f
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Citations in the corpus
- Inflammation, Fracture and Bone Repair (2016, background): “Macrophage populations are highly heterogeneous and plastic [68], making them excellent candidates for immunomodulation of tissue remodeling.”
- Biomaterial based modulation of macrophage polarization: A review and suggested design principles (2015, background): “Therefore, a subsequent transition to the M2 phenotype – which promotes tissue remodeling and repair – is generally believed to be a favorable adaptation [8].”