Fibroblast growth factor signalling: from development to cancer

By N. Turner, R. Grose. Nature Reviews. Cancer, 2010

2,623 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9cb68592898ec9166efb9ba72f4bebb4e524db0e

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Citations in the corpus

• FGF/FGFR signaling in health and disease (2020, background): “Depending on the cellular content in distinct cells and tissues, the classical FGF/FGFR downstream signaling pathways include Ras/Raf-MEK-MAPKs (mitogen-activated protein kinases), phosphatidylinositol-3 kinase/protein kinase B (PI3K/AKT), PLCγ, and signal transducer and activator of transcription (”
• Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. (2011, background): “Abbreviations: BMP, bone morphogenetic protein; FGF, fibroblast growth factor; FGFR, FGF receptor; MAPK, mitogen-activated protein kinase; PCR, polymerase chain reaction; PI3K, phosphatidylinositol 3-kinase; PLCg, phospholipase Cg; STAT, signal transducer and activator of transcription.”
• Network-based stratification of tumor mutations (2013, background): “This pathway has been implicated in tumor proliferation and angiogenesis, and many inhibitors for this pathway are in clinical development 47 .”
• Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma (2017, unknown): “Interestingly, FGF signaling is important for cell migration during embryogenesis while re-activation of the pathway has been linked with cell migration and invasion in prostate tumors (Turner and Grose, 2010).”
• Signal transduction in cancer. (2015, unknown): “For example, whereas FGFR2 is up-regulated in gastric cancers, its expression is reduced in bladder and prostate cancer (Turner and Grose 2010).”
• A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets (2012, background): “As one example, the FGFR2 receptor tyrosine kinase (RTK) has previously been proposed as a potential therapeutic target in gastric cancer.(11) However, most FGFR2-related studies in gastric cancer have been primarily restricted to in-vitro cultured cell lines,(12) 13 and little data is available reg”
• Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration (2010, background): “In addition, there is no human FGF15 gene; the gene orthologous to mouse FGF15 is FGF19 [12].”
• Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. (2010, background): “The FGFR genes are highly conserved, and FGFR1–3 share a tightly regulated mutually exclusive AS event that determines the composition of the third extracellular Ig domain (Turner and Grose 2010).”