Cancer as an overhealing wound: an old hypothesis revisited
By Matthias Schäfer, S. Werner. Nature reviews. Molecular cell biology, 2008
941 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Occupational Therapy, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/500378f63ea479747bac9cb63c4394c87b0fe500
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In Endocrinology, Diabetes and Metabolism
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Citations in the corpus
- Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets (2011, background): “It has long been recognized that chronic injuries and deregulated wound healing are risk factors in the development of cance”
- Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts (2010, background): “The similarities between tumor-associated myofibroblasts and those present in sites of wound healing and chronic fibrosis have long been recognized (5, 27, 28).”
- The extracellular matrix at a glance (2010, background): “The remodeled ECM also promotes the directional migration of cells within the tissue towards the wound site (Schafer and Werner, 2008).”
- Cellular and molecular mechanisms of skin wound healing (2024, neutral): “33) and, while some of these will be linked to cell division, most reflect fundamental roles required by epithelial cells as they navigate through the wound terrain to close the wound.”
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma (2009, background): “com/journals/cc/article/10238 Activated myo-fibroblasts are critical for normal wound healing and are generated via the TGFb mediated differentiation of normal fibroblasts.(1) However, they have also been implicated in a number of human diseases related to fibrosis, such as systemic sclerosis, inter”
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma (2016, positive): “In addition to mesenchymal genes, genes associated with wound healing and angiogenesis, which are considered T cell-suppressive (Motz and Coukos, 2011; Schafer and Werner, 2008; Voron et al., 2014), were expressed higher among non-responding relative to responding pretreatment tumors.”
- Ascorbic acid: Chemistry, biology and the treatment of cancer (2012, background): “Given that cancer development and progression is considered to have an inflammatory component [31], it is highly possible that ascorbate, is oxidized in the extracellular environment, and then taken up by tumor as well as stromal cells [32].”
- Hallmarks of cancer: the next generation. (2011, positive): “Such work traced its conceptual roots back to the association of sites of chronic inflammation with tumor formation, and to the observation that tumors could be portrayed as wounds that never heal ( Scha¨fer and Werner, 2008: Dvorak, 1986).”
- Lactate: a metabolic key player in cancer. (2011, background): “orchestrate the wound-healing process are also important positive or negative regulators of cancer growth and progression (13).”
- Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. (2011, background): “Cancer cells usually go about generating a supportive microenvironment by activating the wound-healing response of the host (4).”