Inflammation in Chronic Wounds

By Ruilong Zhao, Helena Liang, E. Clarke, C. Jackson, M. Xue. International Journal of Molecular Sciences, 2016

1,016 citations recorded by the source corpus.

Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research.

Subfields: Endocrinology, Diabetes and Metabolism, Rehabilitation, Surgery

View Paper: https://www.semanticscholar.org/paper/e1ffa36a40e3c0bd7214bafe581e7a16984628de

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Citations in the corpus

• The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes (2018, background): “In chronic wounds, the proliferative and remodeling stages do not readily occur (Zhao et al., 2016).”
• Drug Delivery Systems and Materials for Wound Healing Applications (2018, neutral): “However, their excess proteolytic activity is associated with chronic wounds because they destroy growth factors, cell surface receptors, and temporary ECM essential for cell migration [29, 30].”