Origin and physiological roles of inflammation

By R. Medzhitov. Nature, 2008

6,251 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3db514274678f6270142f0e68aacd081e0c5443f

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Citations in the corpus

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Metabolic Syndrome: is Nlrp3 inflammasome a trigger or a target of insulin resistance? Circ Res (2011) 108(10):1160–2.”
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “In this perspective, inflammation presumably evolved as an adaptive response to tissue malfunction or homeostatic imbalance (2).”
Transcriptional control of the inflammatory response (2009, background): “jpg" NDATA ITEM> ]> Inflammation is a fundamental adaptation to the loss of cellular and tissue homeostasis with many important physiological roles, including host defence, tissue remodelling and repair, and the regulation of metabolis”
Endothelial Dysfunction and Hypertension. (2016, background): “Additionally, IL-8 stimulates proliferation and migration of ECs and have angiogenic properties (Medzhitov 2008; Levesque et al. 1990).”
Para-inflammation in the aging retina. (2009, background): “that are intermediate between basal and inflammatory states (Medzhitov, 2008).”
Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective (2014, background): “Partial-night sleep deprivation induces an increase in TLR-4-stimulated production of IL-6 and TNF, which is especially prominent in women who show sustained elevations ADRB2 TLR4 Circulation SNS nerve fibers Cardiovascular disease Major depressive disorder Cancer NF-κB Expression of proinflammatory”
From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression (2014, background): “…a rapid innate immune system and inflammatory response to a specific trigger and then down-regulating the response once a pathogen has been cleared are critical for resolving infection, repairing tissue damage, and returning the body to a state of homeostasis (Kushner, 1982; Medzhitov, 2008).”
Reflex control of immunity (2009, background): “1 ) — that interact with Toll-like receptors (TLRs), which transduce intracellular signals, ultimately leading to the activation of NF-κB and the increased release of pro-inflammatory cytokine”
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. (2012, background): “Furthermore, chronic inflammation can sensitize organisms to metabolic stress signals (Medzhitov 2008).”
Inflammation and its role in age-related macular degeneration (2016, background): “These findings suggest that CX3CR1 would play a significant role in maintaining tissue homeostasis, a process which has been termed as parainflammation [157, 158].”
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. (2016, positive): “, and Medzhitov, R. (2014). The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.”