Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

By H. Tissenbaum, L. Guarente. Nature, 2001

2,017 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/3c4776444fff3b2d01d8911b67185a5b517e14b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. L. Guarente
2. D. Sinclair
3. C. Kenyon
4. V. Longo
5. M. Haigis
6. Brian K. Kennedy
7. A. Brunet
8. Laura Bordone

In Geriatrics and Gerontology

1. L. Guarente
2. D. Sinclair
3. Johan Auwerx
4. E. Verdin
5. M. Haigis
6. C. Cantó
7. Bor Luen Tang
8. R. Houtkooper

In Physiology

1. Johan Auwerx
2. L. Guarente
3. D. Sinclair
4. E. Verdin
5. C. Cantó
6. Bor Luen Tang
7. R. Houtkooper
8. M. Haigis

Citations in the corpus

• Calorie restriction--the SIR2 connection. (2005, background): “The SIR2 ortholog in C. elegans was similarly e fshown to be a key determinant of life span in that organism (Tissenbaum and Guarente, 2001).”
• Stressing the role of FoxO proteins in lifespan and disease (2007, background): “1), a histone and non-histone deacetylase, extends lifespan by 50% (Ref”
• Sirtuins in aging and age-related disease. (2006, background): “1, increases the mean life span by up to 50% (Figure 1) (Tissenbaum and Guarente, 2001), and this extension requires the FOXO transcription factor DAF-16, which is known to be regulated by the insulin/IGF-1 pathway.”
• Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. (2007, background): “*Correspondence: david_sinclair@hms.harvard.edu DOI 10.1016/j.cell.2007.07.035”
• FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “The target genes that mediate DAF-16’s ability to increase longevity in worms include MnSOD (SOD3 in worms) (Honda and Honda, 1999), heat–shock proteins, and antimicrobial agents (Lee et al., 2003; Murphy et al., 2003; McElwee et al., 2004).”
• Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan (2003, background): “1, a Caenorhabditis elegans enzyme that regulates lifespa”
• The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, positive): “1, has been shown to prevent aging (Tissenbaum and Guarente, 2001).”
• SIRT1 transgenic mice show phenotypes resembling calorie restriction (2007, background): “The Sir2 gene promotes longevity in yeast, Caenorhabditis elegans and Drosophila (Kaeberlein et al. , 1999; Tissenbaum & Guarente, 2001; Rogina & Helfand, 2004).”