Calorie restriction--the SIR2 connection.

By L. Guarente, F. Picard. Cell, 2005

814 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/2357d5e6bb4417b294930c14a3f3b21470f96dea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. C. Kenyon
2. L. Guarente
3. V. Longo
4. Brian K. Kennedy
5. M. Haigis
6. D. Sinclair
7. E. Verdin
8. Toren Finkel

In Geriatrics and Gerontology

1. L. Guarente
2. D. Sinclair
3. M. Haigis
4. E. Verdin
5. R. Mostoslavsky
6. V. Longo
7. Brian K. Kennedy
8. Toren Finkel

In Physiology

1. E. Verdin
2. D. Sinclair
3. L. Guarente
4. M. Haigis
5. Brian K. Kennedy
6. V. Longo
7. R. Mostoslavsky
8. C. Kenyon

Citations in the corpus

• REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS (2010, neutral): “Among these, Krebs cycle enzyme complexes, such as α-ketoglutarate dehydrogenase (α-KGDH) and pyruvate dehydrogenase have been implicated as significant mitochondrial O2•− and H2O2 sources [5].”
• Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007, background): “It has been proposed that sirtuins mediate the longevity-promoting effects of calorie restriction (CR) in yeast, worms, flies, and mice (4, 17, 22, 24).”
• Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation (2007, background): “Centers-of-Regulated Expression Analysis In Saccharomyces cerevisiae, the chromatin regulatory factor Sir2, a NAD-dependent histone deacetylase, suppresses recombination and silences transcription at multiple genomic loci [20]; its loss is associated genomic instability and aging.”
• The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth (2008, background): “In lower eukaryotes, the SIR2 gene is proposed to mediate the health benefits of CR [2,3].”
• Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (2008, background): “A nutritional diet that is low in calories (calorie restriction) improves health and longevity in a wide range of model organisms, including rodents, in many cases by activating SIRT1 gene expressio”
• Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. (2010, background): “, 2004), and calorie restriction-mediated longevity depends on Sir2 in lower eukaryotes (Guarente and Picard, 2005).”
• A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans (2008, background): “malnutrition, increases the lifespan of many organisms, from yeast to mammals [1].”
• SIRT1 controls endothelial angiogenic functions during vascular growth. (2007, background): “…Cold Spring Harbor Laboratory Press ISSN 0890-9369/07; www.genesdev.org lutionarily conserved and regulates longevity and aging in multiple model organisms (e.g., Saccharomyces cerevisiae, Caenorhabditis elegans) (Imai et al. 2000; Landry et al. 2000; Smith et al. 2000; Guarente and Picard 2005).”
• Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans (2007, background): “In yeast and flies, SIR-2 activity has been associated with the response to dietary restriction ( Guarente & Picard, 2005 ).”
• Sirtuins in aging and age-related disease. (2006, background): “Finally, Sir2 orthologs may have evolved to couple metabolic signals to specific longevity-enhancing functions in different organisms, a model promoted by Guarente and colleagues (Guarente and Picard, 2005).”
• Therapeutic potential of resveratrol: the in vivo evidence (2006, background): “It has been postulated that the main function of sirtuin proteins might be to promote survival and stress resistance in times of adversit”
• Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 (2010, background): “, but the nature of metformin's health-promoting effects is not well understood. Several lines of evidence support that metformin may act by inducing dietary restriction (DR) metabolism, a physiological state triggered by low caloric intake that increases lifespan, delays age-associated functional d”