Stressing the role of FoxO proteins in lifespan and disease

By Armando van der Horst, B. Burgering. Nature reviews. Molecular cell biology, 2007

774 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/de45444482754ef321af9a1d6de5b31c604f1d15

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Guido Kroemer
2. S. Manolagas
3. E. Seto
4. Xiang-Jiao Yang

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Xiang-Jiao Yang
4. F. Pietrocola
5. J. M. Bravo-San Pedro
6. E. Seto
7. Sushil Kumar Jain
8. Frank Madeo

Citations in the corpus

• From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. (2010, background): “OS also promotes other posttranslational modifications of FoxOs, including ubiquitylation and acetylation (64).”
• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “Consistent with this idea, SIRT1- or SIRT2-mediated deacetylation retains FoxO1 in the nucleus (Jing et al., 2007; van der Horst and Burgering, 2007).”
• Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies (2015, background): “FoxO also regulates various biological functions, such as cell cycle arrest, antioxidant response, DNA repair, and apoptosis.(125) Deletion of FoxO1 in diabetic mice reverses the diabetic phenotype.”
• Acetyl coenzyme A: a central metabolite and second messenger. (2015, background): “Other prominent transcription factors that are regulated by CBP- or EP300dependent acetylation as well as by SIRT1- or HDAC1-mediated deacetylation are forkhead box O (FOXO) proteins (van der Horst and Burgering, 2007) and tumor protein p53 (TP53) (Xu, 2003).”
• Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Additionally, posttranslational modifications such as acetylation by CBP/p300 induce FoxOmediated cellular detoxification, cell cycle arrest, and DNA repair or apoptosis in response to ROS (van der Horst and Burgering, 2007).”
• FOXO3A genotype is strongly associated with human longevity (2008, background): “This is consistent with a known role for FOXO as a mediator of the effects of insulin and insulin-like growth factors on diverse physiological functions, including cell proliferation, apoptosis, and metabolism (17, 54).”