R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway
By Qinghua Liu, T. Rand, S. Kalidas, Fenghe Du, Hyun-Eui Kim, Dean P. Smith, Xiaodong Wang. Science, 2003
803 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/37f6aa6b740832465e50d24a755eea89a3e7f22f
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In Molecular Biology
- Phillip D. Zamore
- David P. Bartel
- V. Narry Kim
- Gregory J. Hannon
- Gunter Meister
- Thomas Tuschl
- Richard I. Gregory
- Yukihide Tomari
Citations in the corpus
- Argonaute proteins: key players in RNA silencing (2008, background): “, whereas Dcr-2 and the dsRNA-binding protein R2D2 are responsible for the production of siRNA from long, perfectly paired dsRN”
- Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. (2004, background): “The known functions of a few of these tion is enhanced by an auxiliary dsRNA binding protein,miRNAs indicate that they play widespread roles in R2D2 (Liu et al., 2003).”
- Processing of primary microRNAs by the Microprocessor complex (2004, methodology): “On the basis of the results presented here, Pasha joins RDE-4, Hyl-1 and R2D”
- microRNA-directed phasing during trans-acting siRNA biogenesis in plants. (2005, background): “The dsRNA binding protein HYL1 is also necessary for miRNA biogenesis (Han et al., 2004; Liu et al., 2003; Pham et al., 2004; Tomari et al., 2004; Vazquez et al., 2004a).”
- The role of PACT in the RNA silencing pathway (2006, background): “R2D2, another dsRNA-binding protein, is known to associate with Drosophila Dicer-2 to promote siRNA from entering into Ago2 (Liu et al, 2003).”
- Perspective: machines for RNAi. (2005, background): “Dcr-2 alone can dice long dsRNA but does not stably bind siRNA, whereas the Dcr-2/R2D2 heterodimer binds siRNA tightly (Liu et al. 2003; Tomari et al. 2004b).”
- Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein (2005, background): “two Dicer paralogs define parallel pathways for small RNA biogenesis. Dicer-1 (Dcr-1) liberates miRNA from pre-miRNA, whereas Dicer-2 (Dcr-2) excises small interfering RNA (siRNA) from long double-stranded RNA (dsRNA) [”
- Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. (2005, neutral): “an endonuclease (Liu et al., 2003).”