Processing of primary microRNAs by the Microprocessor complex

By Ahmet M. Denli, B. Tops, Ronald H. A. Plasterk, R. Ketting, Gregory J. Hannon. Nature, 2004

2,868 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c04092f1b2a97a0ff545578fbe75d857485e89c6

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Citations in the corpus

microRNAs as oncogenes and tumor suppressors. (2007, background): “Then, pri-miRNAs form specific hairpin-shaped stem–loop secondary structures and enter a microprocessor complex (500–650 kDa) consisting of a Drosha (a RNase III endonuclease) and an essential cofactor DGCR8/Pasha (protein containing two double-stranded RNA binding domains) (Denli et al., 2004; Greg”
The role of PACT in the RNA silencing pathway (2006, background): “…Molecular Biology Organization |All Rights Reserved 0261-4189/06 www.embojournal.org The EMBO Journal VOL 25 | NO 3 | 2006 &2006 European Molecular Biology Organization EMBO THE JOURNAL 522 pri-miRNAs into pre-miRNAs (Denli et al, 2004; Gregory et al, 2004; Han et al, 2004; Landthaler et al, 2004).”
Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “While the animal primiRNA microprocessor may be minimally defined as Drosha and DGCR8 (Denli et al., 2004; J. Han et al., 2004), microprocessor interactions include the spliceosome-associated components p68 and p72 (Gregory et al., 2004), FUS (Shiohama et al., 2007), and small nuclear RNAs (Janas…”
An overview of microRNAs (2015, background): “The RNA binding protein DGCR8 is associated with Drosha and is required for cleavage of the pri-miRNA[39-41].”
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients (2008, background): “The pri-miRNA is then cleaved by Drosha and its partner protein DGCR8 into an approximately 70-nucleotide precursor miRNA (pre-miRNA) molecule [9-13].”
Perspective: machines for RNAi. (2005, background): “In these efforts, Drosha collaborates with a double-stranded RNA-binding protein, called Pasha in flies and DGCR8 in humans (Denli et al. 2004; Gregory et al. 2004; Han et al. 2004; Landthaler et al. 2004).”
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “However, algorithms based only on WC complementarity show low accuracy and a high number of false-positive results [26].”
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. (2006, background): “, 2004) (known as Pasha in D. melanogaster and C. elegans; Denli et al., 2004), form a complex called ‘‘Microprocessor.”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “In the nucleus, recognition by the microprocessor complex results in cleavage of the pri-miRNA, which is attained through catalytic cleavage of the double-stranded stem by the RNase III endonuclease Drosha, while the hairpin is correctly positioned by DiGeorge syndrome critical region 8 (DGCR8; also”
microPrimer: the biogenesis and function of microRNA (2005, background): “Thus, P-bodymediated miRNA-directed regulation may be a general mechanism among animals. microFunctions miRNAs function in a broad range of biological processes in plants and animals (Kidner and Martienssen, 2005; AlvarezGarcia and Miska, 2005).”