Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.
By Young Sik Lee, K. Nakahara, John W. Pham, Kevin Kim, Zhengying He, E. Sontheimer, Richard W. Carthew. Cell, 2004
1,367 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/40586b7711b201a6c6ba0c518b10c4123fd49822
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In Cancer Research
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In Molecular Biology
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Citations in the corpus
- Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. (2004, background): “Dicer-2, together with the dsRNA-binding protein R2D2, facilitates siRNA loading onto RISC (Liu et al. 2003).”
- A pathway for the biogenesis of trans-acting siRNAs in Arabidopsis. (2005, background): “DCL4 is the only DCL in Arabidopsis that lacks a PAZ domain (Schauer et al. 2002) and resembles the Drosophila dicer DCR2 in this respect (Lee et al. 2004).”
- RNA-based antiviral immunity (2010, background): “melanogaster encodes Dicer 1 (DCR1) and DCR2, which are required for the biogenesis of miRNAs and siRNAs of predominantly 22 and 21 nucleotides in length, respectivel”
- MicroRNA functions in animal development and human disease (2005, background): “Gain-of-function alleles in members of these gene families were found to be due to short deletions in conserved regions of their 3 UTRs (Knust, 1997; Leviten et al., 1997).”
- An endogenous small interfering RNA pathway in Drosophila (2008, background): “Dcr-2 has been implicated in the production of siRNAs from viral replication intermediates or exogenously introduced dsRNAs, whereas Dcr-1 has been linked to miRNA biogenesis 6,16,17 .”
- Induction and suppression of RNA silencing: insights from viral infections (2005, background): “pl?Q9VCU9">DCR1 ) is required for miRNA biogenesis, but dispensable for siRNA-directed RNA”
- Small silencing RNAs: an expanding universe (2009, positive): “, whereas Drosophila species have two Dicers: DCR-1 makes miRNAs, whereas DCR-2 is specialized for siRNA productio”