Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

By K. Reif, E. Ekland, L. Ohl, H. Nakano, M. Lipp, R. Förster, J. Cyster. Nature, 2002

634 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/36445c142a4af73c04b5f74ac0b84a14c71db15b

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Citations in the corpus

Germinal Centers (2017, background): “The powerful combination of morphology and immunohistological methods has proven useful in both diagnostic and research settings [6], and has helped to decipher the roles of gene programs and signaling pathways in controlling cellular dynamics, tissue organization and function.”
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 (2004, methodology): “2 retroviral vector, and retrovirus-containing culture supernatant was generated using the Bosc23 packing cell line as describe”
Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and Homing1 (2004, methodology): “Donor splenocytes were prepared at 10(6)/ml (10).”
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “There is also evidence that T-cell zone chemokines such as CCL21 are bound to the surface of lymph node DCs in vivo and function to capture and prime naive T cells for activation by peptide-MHC.”
FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “Antigenactivated B cells upregulate CCR7 while retaining CXCR5 expression to counterbalance migration to the T-B borders (Reif et al., 2002).”
Structure and function of the spleen (2005, background): “This leads to their migration to the edge of the B-cell follicles, where they receive help from the activated T cell”
Follicular B helper T cells in antibody responses and autoimmunity (2005, background): “After naive B cells bind protein antigens, they upregulate expression of CC-chemokine receptor 7 (CCR7) and are attracted by a gradient of CC-chemokine ligand 21 (CCL21) to the outer T-cell zones of secondary lymphoid tissues, where they elicit T-cell hel”
Aire regulates negative selection of organ-specific T cells (2003, methodology): “Staining for CCL19/ELC receptors was performed as describe”
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. (2004, background): “, 1999) and the antigen-induced migration of B cells from the B cell follicle to the outer T cell area during the initiation of a B cell immune response (Reif et al., 2002).”
Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells (2005, methodology): “cells in lymphoid tissues isolated at various times after HEL injection has established that the HEL-engaged B cells accumulate at the boundary of the follicle and T zone, including in interfollicular regions [5,6,22].”
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2 (2006, background): “After antigen encounter, CCR7 expression is upregulated on B cells, leading to a change in chemokine responsiveness, thus redirecting B cells toward the B cell zone–T cell zone boundar”